ID K1QTL3_CRAGI Unreviewed; 1209 AA.
AC K1QTL3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=CGI_10004418 {ECO:0000313|EMBL:EKC40137.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC40137.1};
RN [1] {ECO:0000313|EMBL:EKC40137.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC40137.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00009903}.
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DR EMBL; JH816105; EKC40137.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QTL3; -.
DR HOGENOM; CLU_000288_140_0_1; -.
DR InParanoid; K1QTL3; -.
DR OMA; ERDKYNQ; -.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:UniProtKB-UniRule.
DR CDD; cd20813; C1_ROCK; 1.
DR CDD; cd22250; ROCK_SBD; 1.
DR CDD; cd05596; STKc_ROCK; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.5.730; Single helix bin; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR015008; ROCK_Rho-bd_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR PANTHER; PTHR22988:SF73; RHO-ASSOCIATED PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08912; Rho_Binding; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF103652; G protein-binding domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51859; RHO_BD; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKC40137.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 1209 AA; 139522 MW; 71ADF7FC8F687697 CRC64;
MSNFDPEYRI RLGKIEERLK DPNSDLNINS LLDGLSALVS DLDHPAIKRN KSVEQFLTKY
GKPVDFVNSC RMRHADFDVV KVIGRGAFGE VQLVRHRSTR RVYAMKLLSK TEMIKRSDSA
FYWEEREIMA NANSEWIVQL HFAFQDSKYL YMVMDYMPGG DLVNLMSNYD VPEKWAKFYC
AEVVLALDAI HSMGFVHRDV KPDNMLLDSK GHLKLADFGT CMRMDRSSGM VRSDTAVGTP
DYISPEVLQS QGRPNHYGRE CDWWSVGVFL YEMLVGDTPF YADSLVGTYG KIMDHKNSLS
FPTDIEISHE AKSLICAFLT DRTERLGRNG IEEIKTHQFF RNIDWTWDTL RQAVPPVIPE
LSSDVDTSNF EDIEKDDSPD ESFAVPKAFT GNHLPFIGFT YNKEYQLLSD SGPSGGNGDK
RFKQLEDQLR AMKAAKEEIE NRYRMAQSDL ERLNREEPML RKECQELEKN LVYLKRDLQE
NQRKLNMELE LKRNLESMLH DKERQLEVEI KSRKEASNSN QQVNEKIYSL EKVITDLNEK
IKAETDSATK YKKSCAELQQ RYNMSEQSYS ELNAKYGEVL SAKQSLQKEV MELQSTLDHE
RNSQRQMSSQ SSELSERISS LMSEKKKAEE KEKELTMEIQ KVKDTVIRLE KSKSHVELEL
DTYKRKLDTE INSHKETIQR FNADKKDILL SKEEARTSAI NDIQNKLDQE KTARASAENQ
LLAAEKEKSG LKVDLLQMTQ QVTAVQNELK NEKEKSKNYS LQVEQEIQRR NLMQGDFKTQ
THDLSRYKNM EKQLNKSLYR TQVKELKEDV EEKGKQYQDA ITDLESVQQD KESFAAQLQL
AMAKADSENL ARSIAEEQLT DVEKEKTMED SKREYSKEIE ELTAEKNDLN SRLQKLSEDL
RQVQSQSGGS SSEIEKLKKN LEEEKLKKIQ AVNKLAEIMN RKEYSSKKSG KNNAADQALK
KKEKEMRKLQ QDLHMEKEKY NKMVEKLGRD LSETQAALFE EGQQKGKLQM ELDAKESEIE
QLRQKLAVSD NVSINSSHLE DGDVLYATEG ENRRPEEIGH DMSAQDKSAV EMHKGHEFVP
IHYRTPTTCD SCNKPVWHML HPPQALECRR CHTKAHKDHL DKNEEFVGYC KVNYDQNIQA
KEMLLLADTS EKQKVWIQHL SKKISRKGFA SSGTAGPTRN TRQYASFGIQ ARQSNARSSS
TLPSNSRPS
//
