ID K1QU75_CRAGI Unreviewed; 576 AA.
AC K1QU75;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Dynein heavy chain 2, axonemal {ECO:0000313|EMBL:EKC37208.1};
GN ORFNames=CGI_10022791 {ECO:0000313|EMBL:EKC37208.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC37208.1};
RN [1] {ECO:0000313|EMBL:EKC37208.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC37208.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; JH817156; EKC37208.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QU75; -.
DR HOGENOM; CLU_473484_0_0_1; -.
DR InParanoid; K1QU75; -.
DR OMA; NRDEVGH; -.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
FT DOMAIN 148..239
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 250..462
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 490..526
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
SQ SEQUENCE 576 AA; 66752 MW; D15F1E114FDA7B11 CRC64;
MSQKITSSNN VQDIIESRVE KRTKGVYVPI GGKKLLTFMD DFNMPAKDTF GSQPPLELMK
LWLDYGFWYD REKQTQKYIK DMFLLAGMGP PGGGRMVISR RLQSRFNLIN MTFPHESQIK
RIFGSMINQK LQDFEEEVKP IGDIMTQATI EMYEAVVQKF LPTPTKIHYL FNLRDISKIF
QGLLRAHKDF HDTKHAMTRL WIHECFRVFS DRDYMNPDNV YEDIQDISQL KKQMTDFLEE
YNSTPGVINM DLVLFRDAIE HVSKIVRVIR QPRGNMLLIG IGGSGRQSLT RLSAYICEYT
TFQIEVTKHY RKNEFRDDLK RLYWQAGVDN KTSVFIFNDT QVVEEGFLED INNVLSSGEV
PNLYKPDEFE EVRNALSDIA KKEGVDDSPQ SIFAYLIERV RANMHIVLCM SPVGEPFRNR
IRMYPAFVNC TTIDWFSEWP ADALLEVADK YLSEISLGSE EESGIRRPAP ATSYSPRVLS
PEATSGHIRL ALESLNKKDM TEIKSYGRPP LLVEKVMEAV MILRGSEPTW AEAKRQLAKM
AELKQQYDEK LAQKEELKRK AEYTELMLER ATKFMS
//
