ID K1QUN1_CRAGI Unreviewed; 827 AA.
AC K1QUN1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=CGI_10019662 {ECO:0000313|EMBL:EKC25276.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC25276.1};
RN [1] {ECO:0000313|EMBL:EKC25276.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC25276.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily.
CC {ECO:0000256|ARBA:ARBA00008874}.
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DR EMBL; JH817691; EKC25276.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QUN1; -.
DR HOGENOM; CLU_006347_1_1_1; -.
DR InParanoid; K1QUN1; -.
DR OMA; NDESVHC; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008349; F:MAP kinase kinase kinase kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06613; STKc_MAP4K3_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR021160; MAPKKKK.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR48012:SF18; HAPPYHOUR, ISOFORM A; 1.
DR PANTHER; PTHR48012; STERILE20-LIKE KINASE, ISOFORM B-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF038172; MAPKKKK; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:EKC25276.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:EKC25276.1}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKC25276.1"
SQ SEQUENCE 827 AA; 93327 MW; A0B2302362B6C023 CRC64;
ARNFSTGELA AIKVIKLEPG DDFAIIQQEI VMMKDCKHSN IVAYFGSYLR RDKLWIAMEY
CGGGSMQDIY HITGPLTEPQ IGFICRETLK GLMYLHNRGK MHRDIKGANI LLTDEGDIKL
ADFGVSAQIT QTMCKRKSFI GTPYWMAPEV AAVERKGGYN QQCDIWAVGI TAIEFAELQP
PMFDLHPMRA LFLMSKSGFK PPQLKDKNKW SQVFQHFIKV ALTKNPKKRP TADKLLEHPF
VLSDHLSRNS TRELLDRVHN PTSPGDFDLQ EDDDGVLQNV PRRISSQNSS QSSAARNSLE
FQVNIPTEHD GDFKTAHSYL DDPVSEMGLL DSVNEELIQR GHENQMSVPA EDIPLSEQST
LQIKPPPRLP KPLPQLPKDD KPEDDGSPRF DDHGPDLDAI LDRELTLVPG ARPPKEADDK
PPELPPKLSK RQNGVLDLGT GAGGGGATEE PPPAVPRRKD RASNMNKADR PVSNGLPPTP
KVHMGACFSK VFNGCPLQIN CTASWVHPDT RDQHILIGAN EGLYTLNLNE IHESSLELLH
ARRCIWVYVI KDVLMTLSGK TTCLFRHDLK MLHSKQANRL SLPMNKIPEK LIPRKFNHTT
KVPDTKGCTQ CCVGRNPYNG YRYLCGALPH GIILMQWYDP LNKFMLLKTF DWDSIPLQPS
VFEMFISPEL EYPMVCMGVR QSSTEMNQLK FDIINLNSSS LWFTEQNDND QLLPVVNVTQ
LEKDTILVCY DNFVRVVNLR GKLKSSRKQS SELHFDFKVE SLVCLQDSVL AFHKHGMQGR
SFKANEVTQE ICDRTRNFRV ILLESRPSDS PSVESNLYVL AGHENNF
//
