ID K1QWH8_CRAGI Unreviewed; 605 AA.
AC K1QWH8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Putative tyrosinase-like protein tyr-1 {ECO:0000313|EMBL:EKC25916.1};
GN ORFNames=CGI_10013418 {ECO:0000313|EMBL:EKC25916.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC25916.1};
RN [1] {ECO:0000313|EMBL:EKC25916.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC25916.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH815935; EKC25916.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QWH8; -.
DR HOGENOM; CLU_012415_1_0_1; -.
DR InParanoid; K1QWH8; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 111..122
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 605 AA; 69103 MW; FAC458C5FD13434E CRC64;
MDNDMERPQE SAMFTSQLVG NGIGPVINGP FAGWLEDGGT MPIVRQIALF NSSLMVKSRM
EIFFEGNEAL RHRDVVNGFG GDGRYTIEGQ HGNVHNWVGG TMSDPFVTAF DPVFILHHTF
IDYIWEKFRQ KIRQQGVNPS TDYPWPMNNY LHRPDNTMYM YDNYTNLDGY SDMFTQYLYQ
YEDMPSCETN CGNSRFLTCR RGVCVSLTAC DIGEESSAQV MGSLSSFGIS LDSLQRPVTA
RFKTVFVDPR TGPGSMTALI DPNSGNFREC ENANHRVRGS LALPFTGMQR VNGGIGQAQL
NEVRTMESLR NSARTRTTNF ENVGDVFRTT NMRSRNLNTP YNPIRRLWDQ SLRFNAFQQS
NHARNFPLAS NNIRSMIHVR LPNLPIQNTF KMGSVFNKRR WVYIPVRIVY TRRPKRYTRP
VVKSPFSFHK SKYPPQVYPF LSNLPKKTPA SFPACLKKPE RFSKVFVQSN GVSYRGQYLD
YAVFDNRHPV SKSIVYVAVK NPKLGVTRSY ITALDSCGRV CRPRCLIRGS NPPAYRPCSG
VVNISSRLPL MYGRTYGEAA KRRRSFAAKR CPSCFHGEIF ITYYCNSGHA LPWKGSRKRI
LRKFK
//
