ID K1QXI2_CRAGI Unreviewed; 619 AA.
AC K1QXI2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN ORFNames=CGI_10020094 {ECO:0000313|EMBL:EKC33650.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC33650.1};
RN [1] {ECO:0000313|EMBL:EKC33650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC33650.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR EMBL; JH823241; EKC33650.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QXI2; -.
DR HOGENOM; CLU_005912_11_0_1; -.
DR InParanoid; K1QXI2; -.
DR OMA; ETVVMWW; -.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF201; SODIUM_HYDROGEN EXCHANGER 8; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT DOMAIN 100..501
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 619 AA; 68728 MW; 33751B82B24E79B2 CRC64;
MKGFTVVMLV LGTLFVPVTE QASPHPQPKS EAVPNITPDP KVNGSFIDVN GTNGTELINS
TTTFTTTIAT TTKRVAVDLP KKGAAEEEHH SSFTIFFILL VVALAILTTH MLIQTRFHYL
PESIADILLG AFAGLLLKIF NSGDPQNREA FNPTVFFIVL LPPIIFESGY NLHKGNFFQN
LGSILVFAIL GTVVSALVVG GGIYLLGQAE VVYKLSWIES LAFGSLISAV DPVATLAIFH
ALDVDPILYM LVFGESVLND AVSIVLTTTV LEYADPSVQI TSKTQAVFSA VGRFLVMFFG
SAAIGVVCGL ISALLLKYVD LRKTPSLEFG LMLTFSYLPY ALAEGIHLSG IMAILFCGIV
MSHYTHPNLS PVTQITTQQT FRTIAFIAET CVFAYLGLAL FSFRLMVKPA FVIWSIALVL
IGRAFNIFPL SLIMNYFREH RISRKNQFIM WFSGLRGAIA FSLSLHLEFE QEKRYVLVTA
TLIIVLFTVI FLGGMTLPIM KCLETKKKKK KSDKEVSLSK TKEMGETVDT DHLSELTEEE
YEVGYIRSHQ KGFPRIDTKY LIPFFTRRFT KQEVKEGRTQ INHLATQWYQ DVRAVPSESD
SEDEAETSLI NHTAEVNHH
//
