ID K1QYZ7_CRAGI Unreviewed; 720 AA.
AC K1QYZ7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=IkappaB kinase {ECO:0000256|ARBA:ARBA00012442};
DE EC=2.7.11.10 {ECO:0000256|ARBA:ARBA00012442};
GN ORFNames=CGI_10012310 {ECO:0000313|EMBL:EKC36399.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC36399.1};
RN [1] {ECO:0000313|EMBL:EKC36399.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC36399.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-
CC seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA-
CC COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC ChEBI:CHEBI:456216; EC=2.7.11.10;
CC Evidence={ECO:0000256|ARBA:ARBA00023939};
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DR EMBL; JH818357; EKC36399.1; -; Genomic_DNA.
DR RefSeq; XP_011455053.1; XM_011456751.2.
DR AlphaFoldDB; K1QYZ7; -.
DR HOGENOM; CLU_000288_101_1_1; -.
DR InParanoid; K1QYZ7; -.
DR OMA; SAIACIH; -.
DR OrthoDB; 2948064at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd12219; Ubl_TBK1_like; 1.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR041087; TBK1_ULD.
DR PANTHER; PTHR22969:SF15; FI05319P; 1.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKC36399.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..310
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 720 AA; 82910 MW; F441B8B272D19B74 CRC64;
MSTYRATENY VYKTDECIGR GATGDVYKGV HKVTGEHCAL KLCDSRFTQQ LQREVEAMRQ
LQHPNITKFY QLEYDKESAK PILVMELCEK GNLLEVLREP SNAFGLPEEE YLRFFSHLVS
GMKHLRQNGF SHRDIKPGNI LVCIADDGSY VYKLSDFGTA KPLKDGDFFQ SLVGTEEYLH
PDIFKAAFIE RHRPREFDIS VDLWSLGATL YHTATGKVPF QPFHGRGDKQ TMFQMISHKD
PGVISGEQTS ATGDIIWSKE LPKTCRLSKY LRDTLTEFLV RLLECQANRM WTFDGFFVAA
DDLLQKHRLY LFSVVDSELY HIYMDPTHRF SELQKCIQEQ TYTHIKSPCF MFHNQDLKES
VSLNEPVRSY PVTSAEEPIV VLPLREGTSL TTRIPVDSIV NLVNELNPKF ESEDSSSRDD
DYRAARSMCS TTALILKAIS QAASACRLLS KSSRDCRYTA RQKYSSLKSS VKNIEDRYGD
IRQIVDSDKT KSTTLFTTIA LDGHVAEEKF EQINNKLEAC ASLLGDCKER HKKLEELTRL
MDCFKQENLR SSVERTSSQM SDILLKFSEY RKSPRLSYHE KKLYGFDKTS MTYHYQRAVS
YLKKVQHSMA STFTSFKRWH SAYIKVIEMH EKVDAATMEV SRQLQEYVSY VKVLKKDPIL
SSVKKPSMKQ RQLAEQVKTR VNVISQDMSE SKQIAQESRI HMESLSSLML DDLEDCDLSD
//
