ID K1R488_CRAGI Unreviewed; 360 AA.
AC K1R488;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Actin-related protein 2/3 complex subunit {ECO:0000256|PIRNR:PIRNR038093};
GN ORFNames=CGI_10025609 {ECO:0000313|EMBL:EKC40553.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC40553.1};
RN [1] {ECO:0000313|EMBL:EKC40553.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC40553.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC involved in regulation of actin polymerization and together with an
CC activating nucleation-promoting factor (NPF) mediates the formation of
CC branched actin networks. {ECO:0000256|PIRNR:PIRNR038093}.
CC -!- SIMILARITY: Belongs to the WD repeat ARPC1 family.
CC {ECO:0000256|ARBA:ARBA00006260, ECO:0000256|PIRNR:PIRNR038093}.
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DR EMBL; JH818947; EKC40553.1; -; Genomic_DNA.
DR AlphaFoldDB; K1R488; -.
DR HOGENOM; CLU_034396_1_0_1; -.
DR InParanoid; K1R488; -.
DR OMA; YVWEPSP; -.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR017383; ARPC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10709; ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR10709:SF2; ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT; 1.
DR Pfam; PF00400; WD40; 2.
DR PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR038093}; Cytoplasm {ECO:0000256|PIRNR:PIRNR038093};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR038093};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
SQ SEQUENCE 360 AA; 39729 MW; 27D3098F9FF60F60 CRC64;
MSAYSFGVTP ITCHAWNGKG DEIAISKNDQ NIEIYKKTSG GYDQTATLSE HGQRVTGIDW
EPQHNRIVTS GADRNAYVWE FQSGAWKPCL VILRINRAAS CVKWSPNGDK FAVGSGSRLV
SICYFEEENH WWVSKHIKKP IRSTITCLDW HPNNVLIAAG SSDFKARIFS AYIKEVESKP
TSTCWGAKMP FANCMFEVSN GGGGWVQDVS FSASGELLAF VGHDSSISVV NGANNQQLAV
LKGAFLPMLS LTWIGPHSIV AAGHDCVPKL FRYSDDGNVT FVNDLDIAQE KEAGTMSAMN
RFRNMDKKAT ADSSTELKTK HQNTITQVSI YSGTKDNCNK FCTTGKDGQM IIWDVKVHVY
//
