ID K1R4Q0_CRAGI Unreviewed; 871 AA.
AC K1R4Q0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Enolase 4 {ECO:0000256|ARBA:ARBA00034855};
DE EC=4.2.1.11 {ECO:0000256|ARBA:ARBA00012058};
DE AltName: Full=2-phospho-D-glycerate hydro-lyase {ECO:0000256|ARBA:ARBA00031125};
GN ORFNames=CGI_10020230 {ECO:0000313|EMBL:EKC36165.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC36165.1};
RN [1] {ECO:0000313|EMBL:EKC36165.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC36165.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 4/5. {ECO:0000256|ARBA:ARBA00005031}.
CC -!- SIMILARITY: Belongs to the enolase family.
CC {ECO:0000256|ARBA:ARBA00009604}.
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DR EMBL; JH821812; EKC36165.1; -; Genomic_DNA.
DR AlphaFoldDB; K1R4Q0; -.
DR HOGENOM; CLU_329624_0_0_1; -.
DR InParanoid; K1R4Q0; -.
DR UniPathway; UPA00109; UER00187.
DR GO; GO:0000015; C:phosphopyruvate hydratase complex; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004634; F:phosphopyruvate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd22974; DD_ENO4; 1.
DR CDD; cd15457; NADAR; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR Gene3D; 1.10.357.40; YbiA-like; 1.
DR InterPro; IPR047500; DD_ENO4.
DR InterPro; IPR000941; Enolase.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR020810; Enolase_C.
DR InterPro; IPR020811; Enolase_N.
DR InterPro; IPR012816; NADAR.
DR InterPro; IPR037238; YbiA-like_sf.
DR NCBIfam; TIGR02464; ribofla_fusion; 1.
DR PANTHER; PTHR11902; ENOLASE; 1.
DR PANTHER; PTHR11902:SF30; ENOLASE 4; 1.
DR Pfam; PF00113; Enolase_C; 1.
DR Pfam; PF08719; NADAR; 1.
DR PRINTS; PR00148; ENOLASE.
DR SMART; SM01192; Enolase_C; 1.
DR SMART; SM01193; Enolase_N; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR SUPFAM; SSF143990; YbiA-like; 1.
PE 3: Inferred from homology;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 64..229
FT /note="Enolase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01193"
FT DOMAIN 240..504
FT /note="Enolase C-terminal TIM barrel"
FT /evidence="ECO:0000259|SMART:SM01192"
SQ SEQUENCE 871 AA; 98424 MW; D7D23B21C627959F CRC64;
MASASTREAR EKYELKQKAV KYYDQNGVPK KMEEILNSMF YDNPDDVYGH LANYFAEHAK
TPLISQLSAA VVSSSSNSSL PENTKPEDRE EEDKAREAGV EAAIALLNGD INTRLQGVDP
ALQSDVDKIL MKLYEELKAE EDERLAKEAA EQAALGGDGA TPVKEEDASV SGKKGGKSSA
KKGKSVAVVV VPDEPKEKLL PGAESICVAS RAACTAASAV REEPLYQHIA TLRFGEIPKD
MRVPIPMVTI IQSGRSAPGK LNCVKEFMVV PKPGMPIADS LKYCQKIYSY VAKTLVTKSG
MAAQYGNDIG ALCPSYDKPE QGLDILQDAI TSLELTPGED FFIALNLAGK EIFDYEKGKY
EVMGGQQKVP EDLVEFWVEL LGRYPSVVAI IDPMRKQEKE HWMRLCDRVS DKCYVIGNHT
YPRPGLLLEE ELTEEFKTSG TVLKLDQINT ITDILESAKK MEDAENQIVL TTCYGETTDT
FLADMVSASM MCPESIPTVS IVPRCPSNAM EWKLAAERKK CDVLGKIQNC TEEDKFMYHC
VLNRDATMLL EVCAPMHYMS GYCARFSELH KRIFNDPALD CAKFDSPCPT RFQSNESYKL
HEENEEEIKR NIDEKRDAGV GFNENKSQED STDQTAETKD TERMEAPVIN NYPNKETREN
CDERKRLNDE ICGQTDANKS RESKPIDRER DRYRLEDEKE KYEYFWQKHS VFSQWYPCTF
VIDGITYNCA EQYMMHQKAE IMGDEDSAKA IMTLDDPSEI KKRGRYVKNF NQDIWGACSQ
EIVKRGNMEK FSQNEELKQQ LLWTHPKTLV EASPYDQIWG IGLSEDDPKA WNKLTWRGKN
LLGEILTTVR EKLRRDIENA GPYGDSNDLD L
//
