ID K1R7D0_CRAGI Unreviewed; 763 AA.
AC K1R7D0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Regulatory protein SIR2 homolog 7 {ECO:0000256|ARBA:ARBA00043038};
DE AltName: Full=SIR2-like protein 7 {ECO:0000256|ARBA:ARBA00041832};
GN ORFNames=CGI_10013956 {ECO:0000313|EMBL:EKC29911.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC29911.1};
RN [1] {ECO:0000313|EMBL:EKC29911.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC29911.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
RN [2] {ECO:0000313|EnsemblMetazoa:G1396.1:cds}
RP IDENTIFICATION.
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EnsemblMetazoa:G1396.1:cds};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the sirtuin family. Class IV subfamily.
CC {ECO:0000256|ARBA:ARBA00038170}.
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DR EMBL; JH817079; EKC29911.1; -; Genomic_DNA.
DR RefSeq; XP_011438129.1; XM_011439827.2.
DR EnsemblMetazoa; G1396.1; G1396.1:cds; G1396.
DR EnsemblMetazoa; G1396.2; G1396.2:cds; G1396.
DR GeneID; 105335756; -.
DR KEGG; crg:105335756; -.
DR HOGENOM; CLU_365729_0_0_1; -.
DR OrthoDB; 1947602at2759; -.
DR Proteomes; UP000005408; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd01410; SIRT7; 1.
DR Gene3D; 2.20.28.200; -; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR003000; Sirtuin.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR PANTHER; PTHR11085:SF1; NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7; 1.
DR PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02146; SIR2; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005408};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}.
FT DOMAIN 99..346
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 204
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 212
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 215
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 242
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 245
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ SEQUENCE 763 AA; 86137 MW; EA6342C23D57FF92 CRC64;
MADEEEQEPN ETSENVEFQT ERSVRQAKKN ARLTQIILKN ERNATTRLVS GILKKAANER
TTEEIDILAK SPELTLRLQK LAKKRDAAKS RHLEVEDPED ELQYKCQQLA EAIRTSNSVV
VYTGAGISTA ASIPDYRGPN GVWTLLQKGQ QPEAQDLSDA EPTITHMCIT QLYRNGHVKH
VVSQNCDGLH LRSGFPRKFL SEVHGNMYIE ICNHCKPQSE YIRLFDVTEK TGVRRHSTDR
SCHSCGKPLK DTIVHFGEKG GLKSPYRWKE AAKAANNCDI ILCLGTSLKI LKKYPCLWCM
DRRLQKRPKL YIVNLQWTPK DDTATLKING RCDDVMRRIF EILRIPLPSY NRVEDPIFTT
YSPLRRNEKL STSKKILKVP IIIQRRKNRR PQKKEMNTVD VPKEEPLKQE ISVDPVTPVD
PLTVNCTVTR TGHVQQPMSP AGSGMRPTPL LNPNNYLFPP TPPFMNGTSQ LPFMQQVFNI
NALLLAANLQ RMSGQFSSSA CEKCRIRLDP NCQCARTLPQ GLGGPFPGFP PFLPFLPQPA
LLDQFRMGMP SVLPLWHPPP QGMYQTPSTS SSTCSTPSYR VQTVLNDHCY LNKAQMQKLS
PQSNASSAPV SPIHSPKQNK VKQTKSSCNE KLNLRSKVLE SPKSSLKQSR TYTSSVRFSL
ESLSSSEEDE KDCLRLNLSD PGIKRENSDS PLDKEDLSDD KSKIAVIAND NLTLGRSVSE
QILNNKTEGE EREVPSRKRK IVRSTSVPGW FGKGLNLKKK RRF
//
