ID K1R7S0_CRAGI Unreviewed; 871 AA.
AC K1R7S0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=CGI_10026441 {ECO:0000313|EMBL:EKC41823.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC41823.1};
RN [1] {ECO:0000313|EMBL:EKC41823.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC41823.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; JH816168; EKC41823.1; -; Genomic_DNA.
DR AlphaFoldDB; K1R7S0; -.
DR HOGENOM; CLU_007287_2_0_1; -.
DR InParanoid; K1R7S0; -.
DR UniPathway; UPA00143; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR040847; SH3_15.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR24202; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR PANTHER; PTHR24202:SF4; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF06701; MIB_HERC2; 2.
DR Pfam; PF18346; SH3_15; 2.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51416; MIB_HERC2; 2.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 871 AA; 95672 MW; BBF34BF5AFC6CA05 CRC64;
MAEGLRVVRG PDWNLGNEDR GEGHVGTVVK DNGDQTYDVY WDMGGKSTCR VGKGGKFDLR
ILDNAPVGVK HLSQRCEGCQ KNTIIGVLWR CASCNDANLC TPCYYLDKHD LSHPFQRIDK
PHGSSVPVPK RSNSVKMKAL GIFPGAKVVR GPNWDFGTQD GGSGKKGKVE DLRGFGSDVG
GRNAVRVRWE TSGEANVYRV GCRGKVDLQC VEEAPGGSYY REHLPVVGKV ERKNEKSATV
DETSESLLKK GDKCVIDMPE VPLKELQRGH GGWSIRMSEC IGEIGVVKNF PNDSTVEIEY
KGKSYQFHAG AVRKVYDVKV GDVVQVLKDE TKAILLQRNH GGWNDDMKKS LGKVGKVVKI
DSDGDVAVAF GNQAWVFNPG LLTPVKGGNV DVLDDGEADT DSYQEEEDDA SGSQDQSERV
QIGADLAQLM AHLLLKGALG AQQLTASPEQ MFNACANGNI GADVEGDTPL HDAIAKRSDR
AVNIILSHPQ INLKLLNKKG HIPLMWAAMK DHEFAVERLI EKEPSLVHAK KSDGYTALHI
AVINDHQDSA NILILKGKAQ VNAQNQQGLS PLHLAAHEGY DKMAKILIEN GADVDLRDND
GDTPLHLALG GRRQTGGNDP LLQLLGLSVN PNAQNQERYN MAVLMLQKGA DFNINNKRGN
SPLEVCRNGE LKRAVTNFIQ KHRSGASGAT SGAEALQELL LELPISCVRC KDSTANTRLL
PCKHKVLCVD CSFKCRVCPL FSLNLAVAIT IAAAAEGALG EDFSISTGPW CWIKGCLSPT
TVIMWMSVTG KFWEVLTYLV SMLFYLGSKY LIWRRTRTQT YSFGENSNYN LRDEDQLYTM
IFLVLVPLRI FGTIRFFIAV HKNLYVDKNP Y
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