ID K1RL30_CRAGI Unreviewed; 1049 AA.
AC K1RL30;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839};
DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136};
DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117};
DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820};
DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031};
GN ORFNames=CGI_10024777 {ECO:0000313|EMBL:EKC42320.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC42320.1};
RN [1] {ECO:0000313|EMBL:EKC42320.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC42320.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
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DR EMBL; JH816160; EKC42320.1; -; Genomic_DNA.
DR AlphaFoldDB; K1RL30; -.
DR HOGENOM; CLU_291216_0_0_1; -.
DR InParanoid; K1RL30; -.
DR OMA; FICETEV; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR041362; TIG2_plexin.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:EKC42320.1}.
SQ SEQUENCE 1049 AA; 115655 MW; 59C5EA1AF63551EB CRC64;
MSVTARTPAS VDNDVITCLL PSNSSLELKP KGTDHHDLEV EFHVGGRAFV KRSVPVFDCT
VHKTCTDCRK SLFNCSWHYQ THTCSALSVD PGTTSYDSCP RVEIPASKNA DIIVHSGDSL
GLVVKLVNMK AGQTDELWCR FRYLDKTETV PGKEESGTLT CDKVQFEYSQ EKSNVDATFE
VLWGPKKFPL DMYNNTTGMC SLLSETKIYK CKYMVTNCGL CLTMDTKYNC GWCNLTNQCT
RNKECPDQWL DRDDTCPNPK ILRFEPSMGP VMGRTNITVS GINLGKDYVD IKGGVKVAGV
NCMVHPDHFE SSQGFKCLTD KVDAPLNGTI TVEVDHLYNT TSDSIFSFVI PNVNLMIPQK
GPLSGGTTLT IFGSHMNAGT LTTVDIAGSP CKVTQMTTEK LMCMTSSSVN GLGEKDVEVD
FGGYKRLLIS KFAYEKDPEI SYIYRNHSIA SGGVMVQICG KRLDMVQKKK LFLEGHEDLA
VDCKEKPTQL GCLLCPTPQL PLSQGERISP DQPRIVHYGL LLDNVLTWKN LSHAPTFSPL
YYYPDPVLEK LSNSADFVKG KSLVIKGSSL STVQPYHELR VTVGSDPCTS IQVSPANITC
IPPEAPEGLR HGKARVQASV VQVGNFHEDV GYLTYSEADN HSHTDKPIAM GIILGVVIPM
IAIIALLTIC IIRRQRKNKQ PEGAIPELLK DHEADEEEEI GMNSMTIKAE MNGQIANGDS
APYISELLAG IEDEAVRQSV SDFLIPRSKL SVGDLIGKGS YGSTSQGQYK NSKGADSEEQ
NEVVAIKSLQ GCSTDKETID NFLKQCAVLK DLQHPNILVM SGVCLSSSEP PLIILPNLQR
GDLKNYIKDS SKNLALVDLL EIAQQVCDAM TYLEGIHVVH GNLAARNCLV ADDKVVKISD
YSIAPLYSGD FYLSNDNISI TRWWAPEILD IEKGATPAFN HKTDCWSFGI VLWELMTRGV
TPYPDVETDN LKKHLTGGHR LKKPRQCPEA IYLLMLKCWT DVPSDRPTFS EITEEIKQFT
STEESSDVSQ PLQTKIEPGG SEEYLGVMG
//
