ID K1S3M7_CRAGI Unreviewed; 393 AA.
AC K1S3M7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Heparan sulfate glucosamine 3-O-sulfotransferase 5 {ECO:0000313|EMBL:EKC42021.1};
GN ORFNames=CGI_10028206 {ECO:0000313|EMBL:EKC42021.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC42021.1};
RN [1] {ECO:0000313|EMBL:EKC42021.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC42021.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
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DR EMBL; JH818444; EKC42021.1; -; Genomic_DNA.
DR AlphaFoldDB; K1S3M7; -.
DR HOGENOM; CLU_017703_0_0_1; -.
DR InParanoid; K1S3M7; -.
DR OMA; GFYCFRR; -.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF69; GH20068P; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Transferase {ECO:0000313|EMBL:EKC42021.1}.
FT DOMAIN 126..365
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 135
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 135..139
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 226
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 328
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 344..348
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 329..339
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 393 AA; 46250 MW; BFE16ED0FA68E8D5 CRC64;
METHRYMYNN LLTSIDTHQA DKFILNDMSM VHNKIKYTAV PVEAENASSK KTFCAYLASH
LTKKNISAFV CILILSTAFV LVACIGGNFQ SKVCTNNKSM QFTPKPQNRL HYPKNLKIAH
SKRRLPHCII IGVRKGGTRA LLQFLKIHPD VQVSPDEIHF FDNNENYSKG VEWYRRRMPQ
SFEEQITIEK SPNYFVDWNT PSRVKLMNSS IKLLLIVKDP FYRAVSDYAQ IKENRIDKNM
EMEEFEDLAI DSMTGNVRIN YKAINRSLYY IHTKRWLKYF PLEQIHIVDG DNLVLHPFEE
LEKVETFLGL RHYIQEDHFV FDRKKGFYCI NRENGAHKCL NRTKGRPHPK IDPDVVDQLN
EFFEPYNQKF FKLVNKTFQW PKAVGKRSIK KKN
//
