ID K1VI40_TRIAC Unreviewed; 4509 AA.
AC K1VI40;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=A1Q2_01798 {ECO:0000313|EMBL:EKD03785.1};
OS Trichosporon asahii var. asahii (strain CBS 8904) (Yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Trichosporonales; Trichosporonaceae; Trichosporon.
OX NCBI_TaxID=1220162 {ECO:0000313|EMBL:EKD03785.1, ECO:0000313|Proteomes:UP000006757};
RN [1] {ECO:0000313|EMBL:EKD03785.1, ECO:0000313|Proteomes:UP000006757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 8904 {ECO:0000313|EMBL:EKD03785.1,
RC ECO:0000313|Proteomes:UP000006757};
RX PubMed=23193141; DOI=10.1128/EC.00264-12;
RA Yang R.Y., Li H.T., Zhu H., Zhou G.P., Wang M., Wang L.;
RT "Genome sequence of the Trichosporon asahii environmental strain CBS
RT 8904.";
RL Eukaryot. Cell 11:1586-1587(2012).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD03785.1}.
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DR EMBL; AMBO01000240; EKD03785.1; -; Genomic_DNA.
DR STRING; 1220162.K1VI40; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; K1VI40; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000006757; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006757}.
FT DOMAIN 1858..1996
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2515..2665
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2857..3023
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3119..3179
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3337..3392
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4509 AA; 509858 MW; F45200F4871C4F4B CRC64;
MASPSPDEGE SFVAAAGGGL GFDVGVFKTY LSALLPPVMS ATRPEIENSL YDDPNFEEKS
LRFATDPGCQ VVYVTKERYV DMDEDANAPL LMADDGTQSA PGTVISTPTA QASPYDGLHS
LVHWGVAPWF DSYVASKGTL NDGPMNKKGN ESQMGIPVTK KKFAELELSL LHLKQNVEIP
EVHLSVHPAI RKAVAQRVSV DAVEPASLIS DQTFLNKLQA DVNSWIKEIQ KVSKLSRDVV
SGTASQEINF WLSMEHALEN IESQLKGEEV TLALDVLKHA KRFHATVSFI ADTGIKEATE
VVHKYNVLMK DFPLDELLAA TDLEKIRESI HMIFAHINKK LKLSPYPIRR TLPLVEAISS
DFNDQLLRVL SAQRLMYMDY SKFEEVMNLT AEVFGAWDDN MKDFTNVARE VSRKRAEKFI
SIKINPAHAK LQERIVYLRG FRRSHEQLRV MTSSTRSFSG LGNDVPFDID MEEEVRLSYE
SVKNVDVLDV TPEGSEIWYA AEVSYNDRVA RIENQIISRL RDKLATTKTA QEMFRVFSKF
NTLFVRPKIR GAIQEYQTRL IDSVKDDIRE LRQKFTANYR NSQAYHMSQL RDFPSVSSAI
IWARQIERQL LTYMKRVEDV LGKGWESYAE GQKLQVESAS FRAKLETKPL YDAWIAEITR
RGNLTVTGRL FDIIRARATS ANQQGNLQLI VQFDPQVVAL FKEVRALIWL GFPVPLTITH
RAKDAKRVYP HAVSLMESVR TYTQTLDLIE QNPDIAILLA TYRNTAQQMI ARGINMQWDH
LVNAYESHRF LAGSEGRESR HFVYVREFAS VVSLLQDKTA ALIDISNDIS RIVEELETCA
YTTEAFSGLL GQVQKTIDQL NLEGYSNLDA WVTQLNERID AALSRRLALA IDAWCAAFTK
ADEEHEADRD TIVDDSKAEI KIKPLIHEVR IRNQVIYLDP PIELARAEWL AQFQNALGVV
CNLNRIRSSR YEITLQVDEA TAEETTYIGL LTSSDKLELQ RPLQLIETKV QSVGAYVDKW
LQFQSLWDLE ADYVYSRLGD SLSNWDLLLS GIRQARSTFD TTDTRKDFGV CVIDYANAQS
KVNAKYDSWQ RDLLAKYGSK LGMTMKETHA AILKARTDLE GYAIEGSSTA HVVAFITFVQ
DLKRKVETWG PEIEQFGTGQ KTLERQRYTF PSDWLYVDQI QGEWSAFSEI LKRKDDSIKE
QVAGLQLKIV AEDKVVDGRI RDFVAEWEEK KPLQGNIKAD IAINTLNAFD SRLTVLQDDY
DLVCRAKEAL DLEHTKDERL QPVTEELRDL KAVWTALTGI WTRLNQLREG AWSAVQPRKL
RQELDSILGS TRDMPSRMRQ YAAFEFVQES IRALLKSNIL ISELKSEALR ERHWTKLYKS
LRLSHSYQPL SMTLGQVYDL DLQKNHALIK EVVVQAQGEM ALEEFLKQVR ETWTSYSLDL
VNYQNKCRLI RGWDDLFSKC SEHLNSLTAM KLSPYYRVFE EDAASWEEKL NRVHVLFDVW
IDVQRQWVYL EGIFSGSADI KHLLPVESSR FQNINSEFLS VMKKVYKSPF VLDVLNIPGI
QKSLERLADH LNKIQKALGE YLEKERSSFP RFYFVGDEDL LEIIGNSKDI HRVMKHLKKM
FAGISILHLD EEATQLNAFA SREGEEVAFR QPIVLKDYPK INDWLAKIES EMRLSLAVLL
SQAVKDLRDI FRIDGDLSPE SLLEWISVYP AQLVVLAVQI AWTELVEMTM PEGKLQSALD
LVSRMLDLLA DTVLQDIPVL QRRKCEHLIT ELVHQRDAMR TLIANGTTSL TAFDWLYYMR
FYLDESIDDP LSRLQVRMAD AVFPYGYEYL GIPDRLVQTP LTDRCYLTLT QALDNQLGGS
PFGPAGTGKT ESVKSLGVQL GRFVLVFCCD ETFDFQAMGR IFIGLCQVGA WGCFDEFNRL
EERILSAVSQ QVQSIQQGLA SAVTNPDTEV ELVGKRLKIN PRTGIFITMN PGYAGRSNLP
DNLKKLFRSM AMTRPDQELI AQVLLFSKGF RTAEILASKI VPFFNLCSEQ LSAQPHYDFG
LRALKAVLAS AGILKRNRHL DGSDDISDEI AEQQIMIQSV TETIVPKLVA DDVPLLRALV
EDVFPGIEYR PVDLGELKAK IAEVCAERRL VVGEAWLDKV IQLYQIQNIS HGLMMVGPSG
SGKSQAWQVL LAALERVDGV EGASYVIDPK AIDKEALYGT LDPTTREWND GLFTHILRKI
VDNVRGETAK RHWIIFDGDV DPEWVENLNS VLDDNKLLTL PNGERLNLPP NVRVMFEVEH
LRYATLATVS RCGMIWFSEE VIDIDMVCQH NLNLLASVPI VSSDEDILEY GAEAAAHQSE
TQKQIATILE PHFGPGGLVR NALEFAAKSE HIMDYTATRA INTLFSLLKA TVRNVIEYNL
HHSDFPLPAD KVEAYVTRRL LLNVIWSFVG DAKLDIRAEL GEQLRLTSGI ETPPMQPGGS
LIDYDVNVAN AEWVSWQSRV PTIEVETHSI TSADVVIPTI DTVRHEEVLY NWLAEHKPLI
LCGPPGSGKT MTLFSALRKL SNLEVVGLNF SSATTPELIL KTFEQYCEYR KTPNGVVLAP
TQIGRWLVVF CDEINLPATD KYGTQRVISF IRQLMERNGF WRTSDLSWVT LERIQFVGAC
NPPTDPGRVP LSHRFMRHAP VVMVDYPGEI SLKQIYGTFN RALLKVVPNL RGSAEALTDA
MVAFYLASQK RFTADVQAHY IYSPRELTRW ARGIYEAIKP LETLSLEGLV RVWAHEALRL
FQDRLVSESE KKWTDDVLDE TAAKYFPNAN MSEALARPIL FSTWTSKNYI PVDREALREY
TKARLRVFHE EELDVPLVLF NDVLDHVLRI DRVFRQVQGH LLLIGVSGSG KTTLSRFVAW
MNGLSIFQIK VSNKYSGADF DDDLRTVLRR AGCKGEKICF IMDESNVLDP GFLERMNTLL
ANAEVPGLFE GDEHAALMTA CKEGSQRDGL MLDSHEELYR WFTQQVARNL HVVFTMNPPA
NGLASRAATS PALFNRCVLD WFGDWSDQAL YQVGLEFTQT LDLESPTYAP PAEFPIAYRD
LAMPPSHRQA VVNAMVFVHQ SMQNITARLA KRQGKYNHVT PRHFLDFINH YVRLFTEKKE
DLEEQQRHLN VGLDKLQATV TQVEELRQSL DAKRSQLNVK DEEANLKLKQ MVADQQEAEA
KKAASVEIQA ALEEQDAYIQ QRSQIVKEDL AQAEPAVIEA LAAVGNIKKQ HLSEVRSMAN
PPETVKLAME SACTVLGFHV DSWKTVQSII RRDDFISSIQ NFDTHKMTKG LRDKMMREYI
SKPAFNFETV NRASRACGPL VQWVIAQVRF SEILDKVAPL REEVASLEEQ AETTKQQAMV
VEETVAELEE SIARYKEEYA LLIAETQSIR AEMERVQSKV DRSMSLLQSL SSEQSRWDAG
SKTFETEMGT IVGDVLISAA FLAYSGFFDQ HYRDTMRRAW MDHLSDAGIR YKSELAIAEF
LSTADERLEW QSNALPADSL CVENAVMLKR YNRYPLIIDP TGQATTFLQN EFRDRKITVT
SFLDEAFLKN LESALRFGNP LLIQDVENLD PILNSVLNRE LRRTGGRVLI RIGNQDIDFS
PSFTMFLSTR DPSVEFSPDI CSRVTFVNFT MTRGSLQTQA LDKVLKVERP EIDQKRSDLM
KMQGEFRLRL RHLERALLQA LNESTGSILD DDKVIETLEV LKREAAEVTS KVEDTDIIMK
EVEAVTAEYL PLASACSSIY FTLEQLANIH RFYQFSLDYF LEIFDYVLHH NPNLKGITDL
EARKTTLFND LFLVTYRRTS RSLLHTDYMV LAATLAKLRL SRSDFSAAVQ EEMDALLEVP
AGTEATEAAL TVEQKRILDS HLGQETTKAL VAHIEANPKE WGAFMADDEA ERNIPWPWAE
ADNIVTSARR LVLVKLFRPD RMVQALATFA NQAFGCDLAQ ISDYDFAAVV KEQVKPTNPL
ALASVPGYDA SYRVDNLCRS LGVTCTSVAM GSVEGFTLAD QAIANAARTG GWVLLKNVHL
APSWLAQLEK RLHSLSPAQG FRLFLTMETN PVVPVNILRQ SRIIMNEPPP GVRANLLDTL
RGLPTLSLKS GPAEKPRLLF LLAWLHAVVQ ERLRYLPLGW SKSYEFNDSD FVAAYKTIDS
WITALAKGKA NVDPAAIPWV ALRTIIKQAV YGGRIDSDYD QRVLDAFVDA VFTPKAYDPD
FALVNLDKPL LVPEGTSMQQ FIDWAQALPE HEPPSWLSLP GTAERNTTVV KLRKMRTTED
DEDDSPAVVD GDGRPAWMTT LKANAQEWLD ALPKRVRKDL SDLIAVCDGQ MKQTNELRAL
LTELNRGNVP PHWARYKMPK GTSVGQYFND LVKRLEQLET VSTSQNYGGG IWLGGLFQPE
AYITATRQAA AHAQGWSLEQ VSLSLRLESS GSPEAFAIKG ESARWLVADI TGLKLHGARW
EDKLVLNDGQ VVSLDTCELA WTKESVEKDT VNVPVYLNGD RGDVLFSANL AADVSAAVVA
ERGLCVTAV
//
