ID K1WCD7_TRIAC Unreviewed; 1000 AA.
AC K1WCD7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=A1Q2_06488 {ECO:0000313|EMBL:EKC99288.1};
OS Trichosporon asahii var. asahii (strain CBS 8904) (Yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Trichosporonales; Trichosporonaceae; Trichosporon.
OX NCBI_TaxID=1220162 {ECO:0000313|EMBL:EKC99288.1, ECO:0000313|Proteomes:UP000006757};
RN [1] {ECO:0000313|EMBL:EKC99288.1, ECO:0000313|Proteomes:UP000006757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 8904 {ECO:0000313|EMBL:EKC99288.1,
RC ECO:0000313|Proteomes:UP000006757};
RX PubMed=23193141; DOI=10.1128/EC.00264-12;
RA Yang R.Y., Li H.T., Zhu H., Zhou G.P., Wang M., Wang L.;
RT "Genome sequence of the Trichosporon asahii environmental strain CBS
RT 8904.";
RL Eukaryot. Cell 11:1586-1587(2012).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKC99288.1}.
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DR EMBL; AMBO01000373; EKC99288.1; -; Genomic_DNA.
DR AlphaFoldDB; K1WCD7; -.
DR STRING; 1220162.K1WCD7; -.
DR eggNOG; ENOG502QUUG; Eukaryota.
DR HOGENOM; CLU_002472_4_0_1; -.
DR InParanoid; K1WCD7; -.
DR OMA; KSYGIFC; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000006757; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006757}.
FT DOMAIN 429..755
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 774..990
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT REGION 72..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 618..645
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 590..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 110553 MW; B66F5A568943A6BA CRC64;
MLSRLGPRAR HCVIGPLALP RGTPVSFGRL LRPKYASSRS GGRRKKEVLA FEDLPVSATT
LQEDLTIGPV EPYLESSKPK RKRKSKSGES PGDDVVRAEY VDISPEEQAE YEAALKAGEI
PETPLSKLVW LNWKRFPDCI LLTQVGNFYE VSSLLGIKLT SKTYKTGQFP FTGFPIHQID
KYLKLLVQDL GYTVALVEEA KDPLQLRDPR DEVKRKVTRV VTPGTLVSES WVSGQESRYL
LALAVGAHAK GDAGLPVYMA YADVSTGEFF TKDTTVNDIE DELTRISPKE IVLDSTYRDA
WLQGTEAVDL DADVGEFLGL LRVLGVHVSF ASTGEEDTTL QRRSAPKPSS ALTLERRAIT
LLRRHLEYAL RDSMPAMPTQ PEEFNRESEQ HQMHIDAPTL QALEIRHALR PGGLMPISTI
PSHLRSPLSV KGTLLSVISR TVTDSGQRLL RRTLSAPSTS LPHINARLAL VASLVDNEDL
RLRLREQMRE LSDVMRTVQK FRSYQGDGSD VWDVARWIRN VEQILARIHE TVREKRRKPV
PTGEQAEGRE RLRQFVEAFR PLSELADTIE GAIDETALNV LQIADESDPE PSPRGTKGEE
EDRKRAERER ALCFSTELSD LHKQIERLKA QRDKLEARLR EEMAAPTLSL GQNVRGAFVV
NVKRKTEIGK LDRSPDFYVM SETRASKTFA NNELEVAHSR ALNRLRAIVI EHSGTVQHNA
ELVDELDVSA GFAQAAVELN YLHVEAGRHP SVESGLLAAS RAFTPNSTHM TPSAYLHVVT
GPNQGGKSTL LRQTAVLAIL AQSGSFVPAD SARIGIVDKV FSRIGARDDL YRDRSTFMLE
MVETATILKS ATPRSLVIMD ESADARIGRG TTLNAGISIA YATLDYILRH IGCRTLFATH
YHELAHMLGA PRSPTAKGDV RPGVAFFCTD VAVDAASGAF AYSYALKPGI NYDSHAIVSF
VRGGVADVQK AAQLAGMPAD FLEIASETLK RLDATKPESS
//
