ID   K1WJA4_MARBU            Unreviewed;      1054 AA.
AC   K1WJA4;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Pseudouridylate synthase {ECO:0000313|EMBL:EKD17720.1};
GN   ORFNames=MBM_04089 {ECO:0000313|EMBL:EKD17720.1};
OS   Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf
OS   spot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Drepanopezizaceae; Drepanopeziza.
OX   NCBI_TaxID=1072389 {ECO:0000313|EMBL:EKD17720.1, ECO:0000313|Proteomes:UP000006753};
RN   [1] {ECO:0000313|EMBL:EKD17720.1, ECO:0000313|Proteomes:UP000006753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MB_m1 {ECO:0000313|EMBL:EKD17720.1,
RC   ECO:0000313|Proteomes:UP000006753};
RX   PubMed=22876864; DOI=10.1186/1471-2164-13-382;
RA   Zhu S., Cao Y.-Z., Jiang C., Tan B.-Y., Wang Z., Feng S., Zhang L.,
RA   Su X.-H., Brejova B., Vinar T., Xu M., Wang M.-X., Zhang S.-G.,
RA   Huang M.-R., Wu R., Zhou Y.;
RT   "Sequencing the genome of Marssonina brunnea reveals fungus-poplar co-
RT   evolution.";
RL   BMC Genomics 13:382-382(2012).
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC       {ECO:0000256|ARBA:ARBA00009375}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH921435; EKD17720.1; -; Genomic_DNA.
DR   RefSeq; XP_007291978.1; XM_007291916.1.
DR   AlphaFoldDB; K1WJA4; -.
DR   STRING; 1072389.K1WJA4; -.
DR   GeneID; 18760024; -.
DR   KEGG; mbe:MBM_04089; -.
DR   eggNOG; KOG2554; Eukaryota.
DR   HOGENOM; CLU_290357_0_0_1; -.
DR   InParanoid; K1WJA4; -.
DR   OrthoDB; 167554at2759; -.
DR   Proteomes; UP000006753; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02569; PseudoU_synth_ScPus3; 1.
DR   Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR   Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR041707; Pus3-like.
DR   InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR   PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006753};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..1054
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003852966"
FT   DOMAIN          774..905
FT                   /note="Pseudouridine synthase I TruA alpha/beta"
FT                   /evidence="ECO:0000259|Pfam:PF01416"
FT   REGION          605..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..993
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1054 AA;  117001 MW;  70A62D045352EC8C CRC64;
     MYAKTALVCA LAGFASASPT PNLQARNMDS NIFTISTSGT PTAIHQLIFN AKDKFFNLNN
     GTSTVCPGME VNCMEAGNTT VFTTRPEANT LFLNSVSAGG QQVYVAADGA LAFLAAHSRD
     FPEGSLTAPF KFKPATAPGQ VGSLKFKGKS FSACKDSATV EKDVWKIWAN AVVGWPAGLR
     VPVDTCLACR GAALQVPIAA HLLSDAVRLL RVDDAVRVRL ASQVALKAEE KDRELALRCE
     DPRGLFDPLG LGVSGGLPLT LGGQDGESVG VDELELEAIR AVEKRDVQDE RLVAVLEEGK
     RAFAAMSDGP FAHTTMGSDQ FREDTNGENA SRSALPTLGI PKQQDRSFRR LDIGHDLYIF
     SSPQWVREFE RKRRRQEERV PVPLYLRITW VILALSIKTL DARTSPRLES VRLKLTSSAS
     PFTSQSGVGI KNTEGNRERV AASETYRKKM EAETGKAQTT AEKYATWSQE KLIERVTQLE
     TELKIKNLSL DTTPEKKSFK KPRTERRFDP SKYSTRLVAF KLAYLGKRYN GFECQKSVTP
     LPTIEEELWK AFNKARLIFP DVVNPRQPGE VNWDGCEYSK CGRTDKGVSA FGQVIGIRVR
     SNRPLAKKRE KRASEEEVQE GADEDVSTST VSPDDPTRGF NSYARPGSVE MASPALAPSR
     LSPQMTPTPD LGLSDPDYEE ALNFDPIADE IPYCSLLNRL LPPDIRILAW CPAPPQDFSA
     RFSCRERQYR YFFTQPAFMP TPPQLEVPTQ KGQTVAMEGK MRDGWLNIKK MREAAKLFEG
     IHDFRNFCKV DPGKQISNFE RRIFYADIEE VDDSTSGLAF VNGADFAPHS TRQAVNPKVY
     TFTLHGSAFL WHQVRHMVAV LFLVGQGLEK PSIVSELLDV ETNPGRPVYE MATDTPLVLW
     NCVFPQEDDA ERKDAIQWHY VGDDPNSGDQ KYGTAGIMDE LWKVWRERKV DEILASTLLG
     VIAKQGRPAG DLSVGEPKKG SRSQKVFDGG DSPRLQGLYT PVMKKLRMET VDVINEKYAV
     RKGFENSAEM KLLGFRRLNN VVASADTPAE KADK
//