ID K1X1R2_MARBU Unreviewed; 2005 AA.
AC K1X1R2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Beta-Ala-His dipeptidase {ECO:0000313|EMBL:EKD18952.1};
GN ORFNames=MBM_03194 {ECO:0000313|EMBL:EKD18952.1};
OS Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf
OS spot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Drepanopezizaceae; Drepanopeziza.
OX NCBI_TaxID=1072389 {ECO:0000313|EMBL:EKD18952.1, ECO:0000313|Proteomes:UP000006753};
RN [1] {ECO:0000313|EMBL:EKD18952.1, ECO:0000313|Proteomes:UP000006753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB_m1 {ECO:0000313|EMBL:EKD18952.1,
RC ECO:0000313|Proteomes:UP000006753};
RX PubMed=22876864; DOI=10.1186/1471-2164-13-382;
RA Zhu S., Cao Y.-Z., Jiang C., Tan B.-Y., Wang Z., Feng S., Zhang L.,
RA Su X.-H., Brejova B., Vinar T., Xu M., Wang M.-X., Zhang S.-G.,
RA Huang M.-R., Wu R., Zhou Y.;
RT "Sequencing the genome of Marssonina brunnea reveals fungus-poplar co-
RT evolution.";
RL BMC Genomics 13:382-382(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC -!- SIMILARITY: Belongs to the peptidase M20A family.
CC {ECO:0000256|ARBA:ARBA00006247}.
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DR EMBL; JH921432; EKD18952.1; -; Genomic_DNA.
DR RefSeq; XP_007291083.1; XM_007291021.1.
DR STRING; 1072389.K1X1R2; -.
DR GeneID; 18759129; -.
DR KEGG; mbe:MBM_03194; -.
DR eggNOG; KOG2276; Eukaryota.
DR HOGENOM; CLU_233831_0_0_1; -.
DR InParanoid; K1X1R2; -.
DR OrthoDB; 177966at2759; -.
DR Proteomes; UP000006753; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR43270; BETA-ALA-HIS DIPEPTIDASE; 1.
DR PANTHER; PTHR43270:SF8; DI- AND TRIPEPTIDASE DUG2-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00105; C5METTRFRASE.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006753};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 190..221
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 348..374
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1176..1297
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1355..1494
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 74..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 2005 AA; 224778 MW; 18DC1A8806B0AD64 CRC64;
MQNTYKTHLE DEEIFQLSLW NGCGQSPFEF AIPPTPLCDP DLPMLTSSAS GEEMEEMIWS
DSDNSQMYGC QSERLAKGKD PPRDSSSPLA RAAKARSLHA QHTGVAAPRA DLSTAEARNE
EPYEAEVLHR VADDTVPGVS LQEKPELAHH LQNDSSILTL AVGSRYIYAG TQDGEIVVWS
LASFELVNRI QAHTRAVLCL FLSGDGNLLF SSAGDAIVNA WCPDSLNRLY HVYSTYDVGD
VFSVAYSTQF QTVYLGAQNT SIQWCSLKES STRPSPCPDN HPDRRNHRFF DSVAVGGKHT
PRPHTTRTGA DDGLVLEIDK SHMMQYAHFG YVYCMLLVRG ITRLVDADED VLISGGGDGT
IKIWKLSYDN SQAIQEVARL GEDDAESVLS MAVDGSFLYS SKLEGVIELW DLDTKQKLRV
IRAHKGDVMT LQMGWGYLFS AGSTGYARKY STVQYGKYQN SILFNQKYHC VNRWKAHEGR
ILASALTTFN GQQLYITGAN DNSVSVWNIT GCDSTKAGKA EVAENQLLKS LQEFVSFKTI
SSRPDHAEDC RRGATFLRTL FNKHGAQTEM LNTDGRHNPV VYARFKGKPA TSGERKKILF
YGHYDVVPAD NKQNKWIIDP FDMKGINGYL YGRGVTDNKG PIMAALYGVV DLIHEKALEA
DIIFLIEGEE ESGSRGFKEA VRRHKELIGD IDYIILANSY WLDDDVPCLT YGLRGVLHAT
VKVDSSHPDV HSGVDGSYMM DEPLFDLTSI LAKLKGLHNR IQIPGFYDSI LPLTAVEEAR
YDDITETLIR RNPENGPPET LKASLMARWR EPNLTVHRYK VSGPDGSLVS SHASAAISLR
LVPNQEVEDV IQSLTAFLTD AFAKLDTHNH LSITIDNQAD AWLGDPDNEI FQTLEEAIMN
VWGPIGEGRC SSVPGPRPKP QALKPGSPAM PSVSPSLKPT PATVTTLTNG SNHTSLAAIP
LEPASLTSLV SSNSANGSKT KGRKPLYIRE GGSIPSIRFL EKEFDAPAAH LPCGQASDSA
HMDNERLRIS NLYKSREIFR QVFKELPRNN PRKPDFSNLP LSEWSDFKGR SQKVGKTNIR
RVPSQNVLGK TWVTPRIFKL WKFFYPNVME RVQLPGIAKG QRVVLESDSE DIMNELRTLV
RDHTSSDAGA YRLGTQIWYN RKLDTQAFAS ITLGGVSYHP GDCVIVASEA QSEEPRFARI
ISIFEDEDDE VSVHLRWFEV GSNTILGETA GPRELFLLTS CDSNPVNCIV AKVKVGFFGD
QNSGRYDSVS DTIDHEDFGF YYRHHWNPNS KQFTSASDHE SNIYLGLGKK SLSGTCHCCK
IMAERLQDEE TRILWDIVPD SKGRGIISGF CSRQVQYRTL DFVYLLPVDH SEPCRIGQIQ
DIYLSRFSEV SKLTSTMVSD HDVRLKVAIY KRYDDLVPSR GQEHEPGRKF GIRDSRRLFF
TGETIKIDGS IVDGVCYVLH RDHVDDLDSF KDQKDTFWVK DRLEEEIDWD SCVRPRDLRP
LDSGSVRYSA TKFEHEKKMI LVREFLERGE KARTLELFNG IGGLTVAFKG ISGITNAVEI
DPAACVTMRN NQPGVIVHKG DASNLLLRAI KRDQGAKLGK LFDGKGNLIP DLPFRDQVDF
IKGGPPCPGY SVANCQKKDG EPKNSLVALY SAYVDFYRPK YSLIENVTGL IHHTLRTPES
NDFKTKPETL ENGTIRMIYR TYTSMGYQVQ CAVLYAEEHG SPQSRPRVII WATQPGCRLP
EYPQPEHLWK TRAACPIFMP GSKLNQSDFH WHRKRRSTPH RVVTLGDAWI DLPEYDIKNP
HLIIPQTRFQ KFEAEQRRNK ITFYDSLDGE SYVGSDNQTY ASGPKSEYQR IMRKGTTDNV
ITAHVTRKLT SINTERVCTI PLVTEANHES LPVALKFRSR NSTPVYSPKK CCRLALDGIH
NVCMTELEVA GKYGNNWRVE DAIRGIGNAV PVPLGASLAE GFLDSWMQYI KNRDRIEPRY
EEPAARNPVR VVHQEVIVIP DSEDE
//
