ID K1Y4B7_MARBU Unreviewed; 4352 AA.
AC K1Y4B7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=MBM_01981 {ECO:0000313|EMBL:EKD20029.1};
OS Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf
OS spot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Drepanopezizaceae; Drepanopeziza.
OX NCBI_TaxID=1072389 {ECO:0000313|EMBL:EKD20029.1, ECO:0000313|Proteomes:UP000006753};
RN [1] {ECO:0000313|EMBL:EKD20029.1, ECO:0000313|Proteomes:UP000006753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB_m1 {ECO:0000313|EMBL:EKD20029.1,
RC ECO:0000313|Proteomes:UP000006753};
RX PubMed=22876864; DOI=10.1186/1471-2164-13-382;
RA Zhu S., Cao Y.-Z., Jiang C., Tan B.-Y., Wang Z., Feng S., Zhang L.,
RA Su X.-H., Brejova B., Vinar T., Xu M., Wang M.-X., Zhang S.-G.,
RA Huang M.-R., Wu R., Zhou Y.;
RT "Sequencing the genome of Marssonina brunnea reveals fungus-poplar co-
RT evolution.";
RL BMC Genomics 13:382-382(2012).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH921430; EKD20029.1; -; Genomic_DNA.
DR RefSeq; XP_007289870.1; XM_007289808.1.
DR STRING; 1072389.K1Y4B7; -.
DR GeneID; 18757916; -.
DR KEGG; mbe:MBM_01981; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; K1Y4B7; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000006753; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006753}.
FT DOMAIN 1933..2071
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2225..2454
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2590..2744
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2932..3098
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3180..3256
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3420..3461
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4352 AA; 493127 MW; 21BDC65688620BA2 CRC64;
MMESLAASPG QTSPKPNETD TFAIDPLIIV EYLASVLEIT LGATRKELEN TGSLLAPESR
SHTIQRCTRF ASENQVALYV TKDIASAGGL DGVIDESSVY LPANSVTYNY TLATDISFSP
STTASIALLK RPYPIDPTIP ITSQVQILNL PGAASLNSST NGQAGSAVSP YEVLHSIVHL
ALAPYFDAYT KNQHSLNGPR GRSEADGKTG VPMTKKRMAE LELSLLHLQQ NIEIPDLVLP
LHPMIQNAVE EAASRNIKPT SEFLPPNLLQ DSTFLNSLQS IVNGWIKSIQ TITKMDRDAA
SGTATQEINF WLSLESALLG IDNQLRTEGV HLTLDILKAA KRFQATISFT ADTGLKETTE
RVQKYNQLMR DFPLDELLSA TSLSKIQDAV DLIFAHLNKK LRICPYPIRR ALPLVELISA
DLDTQLHSML HGRSLMHLEY REFQNLMATA EQIWKIWDEN VKEFTNVARE VTRRRNEKFI
PIKIVPKHAE LQARLKYVST FRDNHEQLQR TIVNVLGPKL GEGDSNGVVL VEEMGDVDAV
EEVQQAYAAL NNVDLLDVTP EGTRVWVQAE ITYNERTSRV ENSIIARLRD RLATAKTANE
MFRVFSKFNA LFVRPKIRGA ITEYQTQLID NVKHDISSLH ERFKQQYGHS EAHAMAQLRD
LPPVSGAIIW ARQIERQLNG YMKRVEDVLG HDWALHSEGQ KLQSESNLFR KKLDTRPIFE
AWLHDVQRKQ ISISGRLFNI NKIRAANNAL ELAVNFDSQV IALFKETRNL LWLNYAVPHQ
INNVSKEAKR VYPYAVSLME STRTLAQTSR QIAQMSDVAI LLGGYQNDVQ NLIIKGIPLK
WESFVHSYEL HTKNSYLNGP LDNAIGGRNE SKHVQFVREF AAAVSLLQTK TAALATTNIT
IQKALGELET CPYDSASFQQ RLEIVQMAVD QLNLENYVNL SYWVREMNAR IKVTLLVRLR
QAISSWIEAF ESERSEGVND DSRRKHLSLS TSLSGEQGPS LKRLVHEVSM RNQVIYLDPP
LAFARANWFL QLHEWLGVVC NLRKVKSSRY EMSLSTGNDT EARFTDLPAS CTDSLSQVYT
CIETKLDHVN AYVDKWLQFQ SLWDLQSEQV YEELGEQLSK WLQCIQDIRK VRSTFDTTEV
SRSFGHLSID YDQVQTKVNA KYDQWQHEIL TKFAVRLGIR VREVYSEIEK ARKDLEVQSL
EATSTAQAVQ FITIVQTCKR KVKAWGPEVD IFRQGQTTLV RQRYQFPADW LNVEQVDSEW
MALNEILARK AKIVQDQTDA LRAKITAEDK VVGDKIVEIT GQWNEEKPVS GTIAPDVASA
TLMSFEARIT RLHEDSEMVS RAKEALDLPA NPDTTLTAIL EEVQDFKSVW AALSTIWKSL
NELREALWTQ VQPRKLRSSI DGLIKMTKEM PSRMRQYAAF EHIQNILRQF LKVNPIIADL
KSEAVRERHW NKIFKALKPG KRYSPISMTL GDVWDLHLAA SEVVIRDIIA QAQGEMALEE
FLKQVREIWS NYSLDLVNYQ NKCRLIRGWD DLFAKCSENL NSLQAMRHSP YYKEFEEEAS
SWEDKLNRVH VLFDVWIDVQ RQWVYLEGVF TGNADIKHLL PIESSRFQNI NSEFFAVMKK
VYKQPFVLDV LNISGVQKSL ERLAELLNKI QKALGEYLER ERVSFPRFYF VGDEDLLEII
GNSNDTLRIA KHFKKMFAGL SGLIMDEDHL ISGFTSKEGE EVRLKKEISL IKTPKINDWL
ALLESSMKST LAELLAEAIE QYEPIFNSEE VEQASLNAYI SAFPSQIVVL ATQAVWTSTV
EKSLEAGGST LEHLYEQEVK VLRLLAATVL GDLDPIQRKR CEHLITECVH QRDVIEKLKN
MEASSPTHYH WLLQMRYVYK AEGDWLQRLH IKMANATLNY GFEYLGVAER LVRTPLTDRC
FLTLTQALCQ RLGGSPYGPA GTGKTESVKA LGVQLGRFTL VFCCDDTFDF QAMGRIFLGI
CQVGAWGCFD EFNRLEERIL SAVSQQVQNI QLGLKQGMED EKSQIELVGR QLRVNANTGI
FITMNPGYAG RSNLPDNLKK LFRSVAMSKP DKELIAEVML YSQGFNQAKQ LSKQTVPFFD
SCAAKLSKQA HYDFGLRALK SVLVSSGGLK RARLTDSGGD LGPEEEVEPQ IIVQSIRETI
APKLIKSDVE IMRSIEAESF PGVQYVPATL KELKAAIHSI ADERHLVMNP TWMTKILQLY
QIQTIHHGVM MVGNSGSGKS VAWKLLLQAL QQVEGVEGVC HIIDSKVMSK EALYGNLDST
TREWTDGLFT SILRKIVDNL RGEEAKRHWI VFDGDVDPEW VENLNSVLDD NKLLTLPNGE
RLNLPSNVRI MFEVETLKYA TLATVSRCGM VWFSEDTVTS NMMVSNYLDT LRAVALEDLD
EDAVSTGQTA AKALALQGQV ADLLDAFLTT GDFILNALER ARGFNHIMEF TVARVLNTLF
SLLNKGVRDI IEYNNQHVDF PLDPDQVESF IAKKLLLALV WSLTGDCPLG DRKSFGDCLA
GLATFGSPIM GDNSSLIDYD VTLPKAEWIP WQNSVPTIEV NTHSITQTDV VIPTLDTVRH
EDVLYSWLAE HKPLLLCGPP GSGKTMTLFS ALRKLPNMEV VGLNFSSATT PDLLIKTFEQ
YCEYKKTLNG VILSPTQIGR WLVLFCDEIN LPAPDKYGTQ RAISFLRQLV EQNGFWRTSD
KTWVTLDRIQ FVGACNPPTD AGRTPMGARF LRHAPLVMVD YPGELSLQQI YGTFNSAVLK
IIPSLRGYSE SLTKAMVQFY LESQQRFTAK IQPHYVYSPR ELTRWVRGIY EAIRPLETLS
VEGLVRIWAH EALRLFQDRL VAEDERNWTN DAINRTALDH FPTIEQDKAL GGPILFSNWL
SKNYVPVDRE QLREFVRARL KTFCEEEVDV PLILFNDVLE HVLRIDRVFR QPQGHLILIG
VSGSGKTTLS RFVAWMNGLK VFQIKVHGKY SAEDFDDDLR DVLRRSGCKG EKICFIMDES
NVLDSGFLER MNTLLANAEV PGLFEGDELA SLMTACKEGA QRQGLLLDSQ EELYKWFTGQ
IVKNLHVVFT MNPPEDGLSS KAATSPALFN RCVLNWFGDW SDQALFQVGT ELTQRVDLDR
PNFTAPDSIP VAYRDLVLPP SHRAAVVNSM VYIHYSLHRF NVKLLKQQNR VTFLTPRHFL
DFVAQYVKLY NEKREDLEEQ QRHLNVGLEK LRDTVDKVRD LRVSLAEKKD QLERKDAEAN
EKLQRMVADQ REAEQRKTTS LEIQAALEKQ EVEVSERREL VLNDLASAEP AVLEAQKSVS
NIKRQHLTEV RSMGNPPAGV KLALDSVCTL LGHKVDSWKT IQGIVRKDDF IASIVNYDNE
RQMTKNLRIK MRNEYLSNDD FTYEKVNRAS KACGPLVQWV QAQVNYSEIL DRVGPLREEV
GMLEEQALQT KAEAQAIENT INTLEQSIAT YKTEYAALIS ETQAIKTEMT RVQFKVDRSV
RLLDSLSSER VRWEEGSKSF ETQIATLVGD VLVAAAFLAY SGLYDQQFRK NMMDDWLHQL
QMSGIDFKQH NPITEYLSTA DERLGWQENS LPVDDLCTEN AIILERFNRY PLIIDPSGRV
TDFLQKQSQD RRLTVTSFLD DSFTKQLESS LRFGNPILIQ DAEYLDPVLN HVLNKEYQKT
GGRVLIQLGK QEIDFSPAFK IYLSTRDPSA TFAPDICSRT TFVNFTVTQS SLQTQSLNEV
LKSERPDVDE RRSNLIKLQG EFKVHLRQLE KRLLQALNES RGNILDDDNV IETLETLKKE
AAEISIKMSN TEGVMTEVDE ITLQYNIIAR SCSAVFAVIE QLHYLNHFYQ FSLQYFLDIF
HSVLHGNKRL TNETNHNVRR DIIIEDLFIT TYQRTSLSLL QKDRITLAML LAQAAPYKMD
KTLIDVILDE SIEGTDVSTE SHKKDEVLAR AVKLAALRGK LEVVSPEAWE RFLFEEMGEK
YVPQIWEDNV EKRDQELLSL LLVKLFRLDR FVPAAERFVT AVFGPGIFDT TEDLKDTVEQ
VSASRPIALC SSPGFDASYK VDNLVERSRA ACTNIAMGSN EGPATADKAI ANAAANGSWV
LVKNVHLAPT WLQSLEKRMD SLKPQANFRL FLSMESSPKI PVNLLRASRV LMYEQPAGVR
ANMKDSMTSL STRATKNPVE RTRLYLLLSF LHAVVQERLR YAPNLGWKGF WEFNDSDYEC
SAFIIDTWVE AVAMGRTNVA PQNLPWEMIR TLITETYGGK IDDEGDFARL NQLVNSFMTP
AAYDIGHKLV EGVAGNGTSD VDGSLVVPSG TTLTDFTEWI KNLPEREPPT YLGLPANAEK
LLLVGQGLSM IQNLGKITEL LDEGEQLMAE AA
//
