ID K2JQ56_9GAMM Unreviewed; 946 AA.
AC K2JQ56;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Protease 3 {ECO:0000256|ARBA:ARBA00017565};
DE EC=3.4.24.55 {ECO:0000256|ARBA:ARBA00012449};
DE AltName: Full=Pitrilysin {ECO:0000256|ARBA:ARBA00033450};
DE AltName: Full=Protease III {ECO:0000256|ARBA:ARBA00031184};
DE AltName: Full=Protease pi {ECO:0000256|ARBA:ARBA00029597};
GN ORFNames=B3C1_01415 {ECO:0000313|EMBL:EKE77428.1};
OS Gallaecimonas xiamenensis 3-C-1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Gallaecimonas.
OX NCBI_TaxID=745411 {ECO:0000313|EMBL:EKE77428.1, ECO:0000313|Proteomes:UP000006755};
RN [1] {ECO:0000313|EMBL:EKE77428.1, ECO:0000313|Proteomes:UP000006755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3-C-1 {ECO:0000313|EMBL:EKE77428.1,
RC ECO:0000313|Proteomes:UP000006755};
RX PubMed=23209203; DOI=10.1128/JB.01854-12;
RA Lai Q., Wang L., Wang W., Shao Z.;
RT "Genome Sequence of Gallaecimonas xiamenensis Type Strain 3-C-1.";
RL J. Bacteriol. 194:6937-6937(2012).
CC -!- FUNCTION: Endopeptidase that degrades small peptides of less than 7
CC kDa, such as glucagon and insulin. {ECO:0000256|ARBA:ARBA00002184}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE77428.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMRI01000002; EKE77428.1; -; Genomic_DNA.
DR RefSeq; WP_008482418.1; NZ_AMRI01000002.1.
DR AlphaFoldDB; K2JQ56; -.
DR STRING; 745411.B3C1_01415; -.
DR PATRIC; fig|745411.4.peg.274; -.
DR eggNOG; COG1025; Bacteria.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000006755; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006755};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..946
FT /note="Protease 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003859379"
FT DOMAIN 52..189
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 215..390
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 396..669
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 674..850
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 946 AA; 104939 MW; F00251C156DF6B8C CRC64;
MLLRTSTLVL ALGLALAGCQ QVSAPQPAPG TIITSPADSL HYRYLALDNG LKVVLASDPD
ADKAAASLVV HVGHTADPKD RQGLAHFLEH MLFISTDKYP KVDEYRQFIE THGGSSNAGT
GQVDTTFFFN IAPDQFAPAL DRFAQFFIAP SLDPAYVDRE KHAVYSEFEL KKQDDGRRIN
EVLKATANPA NPASQFSVGD LETLADRPGD KVWADLKAFH DKYYHAGNMT LALVGKEDLD
SLEAYARQYF AAIPKGKANP VQPTAAPYLP SQLGVRIDQA PLKDQRTLSL QFPVPNSQAH
FLAKPLDYIA NMLSNAAPGA LYSELKGKGW VDSLSAYHYG PDDYELFNLD FNLTEAGAEH
LDDITQATFA YIHKLQAQGV TEAYFDELRK AGNLDFRFQE KASALSLANY LASNLQQVPP
LHLMDAGFLY QDFEPELIQG YLARLTPDNL RQLVVLPGAN TDKVEPRYQA PYKVSALSPE
LKDKWASAQA DLALPPDNPY LAEDPRLKAL AENHPLPKKV VEEQGLSIWA LQDPEFRVPK
VEKRVSLTRP MAGATESAMN SLYADLINEA LESEAYPASQ AGLYFGLSAT SLGLSYSLSG
YDEKQPLLED KIWTALHLPG LTQAKFNQYR DALVRNWRNL HQEWPVNQVM ARLGSTLVRE
SYDADSKADA LEKVSFRQFQ GFVAHYPDQL NLRAMAIGNL TDAEVASWGK SLENLLLREA
KRIDKPLMHL AQLPAGKELG LKLDIDHHDA VLAMIYKGHQ QDATSQARYA LMGQILSAPF
FGKLRTEQQL GYVVQAGYSS LGRSPALFLL VQSPVADPFA LRQHMDSFSK DFTATLAAMT
PAQLDEQKAG LINSINQADK QLGDKTDRYW SYLGNGRPFD WRQQLVAAVQ VLTLADLQEF
YQQQVLDDKD GRLLLWSQGQ QAKSGDMPKA CTNQACLDKL WQYKGE
//