ID K2JRU9_9PROT Unreviewed; 317 AA.
AC K2JRU9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EKE77222.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:EKE77222.1};
GN ORFNames=P24_05557 {ECO:0000313|EMBL:EKE77222.1};
OS Oceanibaculum indicum P24.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Oceanibaculaceae; Oceanibaculum.
OX NCBI_TaxID=1207063 {ECO:0000313|EMBL:EKE77222.1, ECO:0000313|Proteomes:UP000006746};
RN [1] {ECO:0000313|EMBL:EKE77222.1, ECO:0000313|Proteomes:UP000006746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P24 {ECO:0000313|EMBL:EKE77222.1,
RC ECO:0000313|Proteomes:UP000006746};
RX PubMed=23209207; DOI=10.1128/JB.01859-12;
RA Lai Q., Shao Z.;
RT "Genome Sequence of Oceanibaculum indicum Type Strain P24.";
RL J. Bacteriol. 194:6942-6942(2012).
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE77222.1}.
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DR EMBL; AMRL01000005; EKE77222.1; -; Genomic_DNA.
DR RefSeq; WP_008943723.1; NZ_AMRL01000005.1.
DR AlphaFoldDB; K2JRU9; -.
DR STRING; 1207063.P24_05557; -.
DR PATRIC; fig|1207063.3.peg.1124; -.
DR eggNOG; COG1250; Bacteria.
DR Proteomes; UP000006746; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:EKE77222.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006746}.
FT DOMAIN 7..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..252
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 317 AA; 34521 MW; C2AFE84908AF305D CRC64;
MGGDKGTIAV IGSGLIGRAW SICFARAGHK VKFHDVSKPA LDAALGLIDG ALKELHESGL
LDDPAAAKAR ISTAATLEEA LEGASYVQEN VKETEEAKQE IFAVMDRIAD PGAILASSSS
NIRASLFTED LKGRARCLVA HPANPPHLVP IVELSPAPWT DPEVVARARA LYEQAGMVPI
LVKKEIPGFI LNRLQGALLA EAFKLVADGY ASTEDVDKTI KDGLGLRWSF MGPFETIDLN
APAGVADYIA RYAPMYWDMQ HEQAQPRRWD KALSDVLEGE RRQALPADRL GERQGWRDRR
LMALIAHKRE AAKKIGE
//
