ID K2JU78_9PROT Unreviewed; 752 AA.
AC K2JU78;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:EKE78052.1};
GN ORFNames=P24_03465 {ECO:0000313|EMBL:EKE78052.1};
OS Oceanibaculum indicum P24.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Oceanibaculaceae; Oceanibaculum.
OX NCBI_TaxID=1207063 {ECO:0000313|EMBL:EKE78052.1, ECO:0000313|Proteomes:UP000006746};
RN [1] {ECO:0000313|EMBL:EKE78052.1, ECO:0000313|Proteomes:UP000006746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P24 {ECO:0000313|EMBL:EKE78052.1,
RC ECO:0000313|Proteomes:UP000006746};
RX PubMed=23209207; DOI=10.1128/JB.01859-12;
RA Lai Q., Shao Z.;
RT "Genome Sequence of Oceanibaculum indicum Type Strain P24.";
RL J. Bacteriol. 194:6942-6942(2012).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE78052.1}.
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DR EMBL; AMRL01000003; EKE78052.1; -; Genomic_DNA.
DR RefSeq; WP_008943309.1; NZ_AMRL01000003.1.
DR AlphaFoldDB; K2JU78; -.
DR STRING; 1207063.P24_03465; -.
DR PATRIC; fig|1207063.3.peg.701; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG2931; Bacteria.
DR Proteomes; UP000006746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 2.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF00353; HemolysinCabind; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00313; CABNDNGRPT.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF51120; beta-Roll; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 2.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000006746};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 378..520
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 48
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 90
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 289
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 752 AA; 78349 MW; FD689D475493E873 CRC64;
MLPTDTYFPY QWHLINTGQD GARVGVDLNV VPVWQDYTGK GVIVGIYDSG VQVGHPDLSA
NFDPALQPTT VFGPHDPDPV DGRFVTQDGH GTAVAGLILA ANNGFGVVGV AYDATFGAVN
LILSDSYESD NEAGDATELT ALNYQMALYD VINHSYGPDT PFISNFTEFE NFANLASMDR
AALLGRDGLG TVHVVAGGNE RTDGNMTTYG DLGNLRYTIN VAAGSAEGDI LYYSNPGASL
VVTAPVDRNP GDDGFKSVTT DLLAGLGYSG SNNAEIDSSD YSDQMNGTSA AAPMVTGVVA
LMLEANPLLG YRDVQEILAL TARANWQEGA YELYDWQTNG ATYWNGGGLE FSHDYGFGFV
DALAAVRLAE SWTDQRTRYN EQIEVVEALD IDTAIPNTGV PLSYSFEVEA DFTVEWVELA
VGLDHSWWGD LTVTLLSPDG TESVLMNRPG VTPDTNAGLD IPVSASGFEG EDELQFIFAS
NAPRGELADG AWTVTVTDAG AAGFGVLEDL TLLLYGRPEE DVQTFYYTDR YADLAAEQAG
RQSLQTDGPA KINAAAVSGD VVIDLSPGML GSIAGADFTL VAGSIVTEIL AGGGNDSLTA
SDIGTILAGA HGHDALTGGA GADLLEGNKN ADTLVGGLGD DTLRGGKGHD RLDGGGGNDV
MHGGLGENIF AFADGSGIDT IMDFGIGRDR IEVSQGINGT NISTAADLLA LVASDIAGNA
VLDLGSGNHV TLVGVAAAAL AEDHFLISAP IA
//
