ID K2KT85_9GAMM Unreviewed; 4496 AA.
AC K2KT85;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:EKE80855.1};
GN ORFNames=A10D4_11184 {ECO:0000313|EMBL:EKE80855.1};
OS Idiomarina xiamenensis 10-D-4.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Idiomarinaceae; Idiomarina.
OX NCBI_TaxID=740709 {ECO:0000313|EMBL:EKE80855.1, ECO:0000313|Proteomes:UP000014115};
RN [1] {ECO:0000313|EMBL:EKE80855.1, ECO:0000313|Proteomes:UP000014115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-D-4 {ECO:0000313|EMBL:EKE80855.1,
RC ECO:0000313|Proteomes:UP000014115};
RX PubMed=23209204; DOI=10.1128/JB.01855-12;
RA Lai Q., Wang L., Wang W., Shao Z.;
RT "Genome Sequence of Idiomarina xiamenensis Type Strain 10-D-4.";
RL J. Bacteriol. 194:6938-6938(2012).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE80855.1}.
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DR EMBL; AMRG01000015; EKE80855.1; -; Genomic_DNA.
DR RefSeq; WP_008489591.1; NZ_AMRG01000015.1.
DR STRING; 740709.A10D4_11184; -.
DR PATRIC; fig|740709.3.peg.2260; -.
DR eggNOG; COG3321; Bacteria.
DR OrthoDB; 9787298at2; -.
DR Proteomes; UP000014115; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR CDD; cd08953; KR_2_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR049490; C883_1060-like_KR_N.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF21394; Beta-ketacyl_N; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000014115};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 27..453
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1483..1558
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1582..2009
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3025..3100
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3126..3552
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4404..4479
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4496 AA; 493678 MW; FC67159AC7BDED9D CRC64;
MSEDNKLSLA KKALLERLSA NNNSEEHIDI AIVGMAGRCP GADDVATMWD NIVEGRETIT
TFTDNELLDA GVPAAIFNDP NYVKKRGIIE NIDMFDAGVF GFNPREAELM DPQHRVMLEV
AFTALENAGY DSQRFDGPIG VFAGTMQSHY QMHLHADKEL WATLDPFDIS LANIQDSMCT
RISYKLDLNG PSFSVGTYCS TSGVAIHLAC QSLRSGESDM ALAGAISLHV PTKHGHLFEP
NNQSSPDGHT RTFDERAQGT VFSDGAGMLV LKRLDDAIED GDTIHAVIKG SAINNDGSLK
AGYTAPSVER QAEVITLALE DAGLEPEDIH YIEAHGTATE LGDPIEVTAL TRAYREYTDK
KQFVTLGSIK TNFGHTDRAA GVIGVMKAAH VVRTGIAPPT LHFDKPNPKM DLENSPFTVR
NTAYQFPEMD VPRRAGITAL GVGGTNAHII LEQPPEPEHM DEGRRWQFLS LSAKNHTSLD
KMRENLAIAL ESDPQVALAD AAYTLYCGRR EYGERLAVVG DSREALIKAL RERPQERFIQ
SALPATKQPI AFMFTGVGEQ YVNMANDLYV QDDDFREDMD HCFDVLEGIL GHDLRDILFV
DDMPVFDRAK AMLLGRMPDD EFSAELNRTI NAQPCTFVVQ YCLANHLLRC GVSPEAVVGY
SLGEYAAAAM AGIFSIQDAL KLVAERAKLI ESLPEGSMIA VPMEVSALEA LLTSLDEQVD
IGIINGPKLT IAAGADSAID ALEGLLSNKN IMCRRLSTSH AFHSSMMSPA KDKLRTLLSE
IDLNPPTMRF LSNVTGTWVT SEQAMDPQYW IDHMCQTARF GECIDTLFED GDWTLVEVGP
GQSLSSLIKQ RATVHGDDSG IFTVQTMRTL YVDDDDEAVF TAALAKLWVL GSGPNYLRYY
DGESRRRIPL PTYAFDRQSY WIETAEQDVS LSQQLMMSQE PKAELADSFY FPQWESDGAA
VDDLSNLNIN TPQNWLVFAD ADGLCQTLAE TVKPHGINCV LAFHGKHYNA NKDGSFDIRP
GSKKDLDAMF KALKKSTKLP SRIVYGWTAA RYDEQMDIQL QVNLGFYTLF QLAKSIGDYL
IDTDLELCIL SADMQAVIGN EPIIPSKALV KGPTKVIRQE FANVACRSID AFTLGMGAVD
IALLAKQLAC ELLLGAQDQF VALRNNTRYL PLIEKVRMEA PLEGNSRLKE NGVYMITGGM
GGIGLAIAEH LYRTQKARLV LIGRSALPEQ SEWNAICEAN ESDRITERVK KINALVKAGA
EVMVIVADVA DEQAMATVAE DAIERFGELN GIIHAAGVPG QGLTQLKTVE AAEQTLRSKV
QGTLAIAKAV EHVELDFFIL VSSIAAFSGG GAGQIDYCAG NAFLDAYALA HQYDHGTTIA
INFGEWQWDA WSDGLQGFHP ELREAMIKHR QNFGITFEEG MEAIRRILAI DVPQVIVLPE
DAIAMIRGSN VCSVAKLAEV VQSNHSRKKT AYPRPALATS FVAASNDLEK TIAEIWQNLL
GIDEIGTKDN FFDLGGNSLV GLQIVADLRR ELDIDVPQVI LYEAPTVEAM VKLLAPDVHS
EGPDEREIFD ARRAKVQNGT GARDIAIVGM SGRFPGARSP TELWENLRDG VEAISFYSES
ELIEAGVSPA EFRKSNYVRA GFDIENIDHF DARLFGYSPR EAEFIDPQHR QLLECAWAAL
EDAGCDPESF KGLIGIFAGS NASNYLLNLM SRQDLMDSPV AGLQVGVGNT VDALATRIAY
KLNLKGPALS VQNFCSTSGV AMHMACKSLL SGECDVAMAG GVNIAVSGKE GYLYEEGGIN
SPDGHVRTFD ADSKGAVIGD GVGVVVFKRL ADALEDGDNI YAVVKGSAIS NDGSLKVGYT
APGVDGQTNA VSAALRVAGI NPESIQYVEA HGTATELGDP IEVTALTKAY RQSTDSKNFC
AIGSIKPNTG HLDRAAGVAG MIKTVMSLKH EEIPPLLHFK APNPNIDFEN SPFYVAAQKQ
PWPGGDIPRR AGVNVVGLGG TNAHFILEEA PVIEPSDRSR RYQVLMLSAN TQWSLDAAKQ
RLADHLSDNP TQNLADIAYT LQTGRQRLEF RQAVVCSDHQ NAIDGLLDEK LSAFLSGHLA
GGNKSLVFMF PGVGDHYNNM AVDLYHNEST FRSEFDHCCE VLEPLLGVDL REILFTETES
KQEQEKPAFD IKAMLSGDGQ GTSSCSVLQQ TWLAQPLVFA VEYCLAHQLM SWGYVPQAVI
GYSLGEFVAA TVAGCVELND ALALVAKRAR LINDLPSGSM LAVPMSESEV ESLLVENVDI
ALCNSPKTTV VAGTDDGIDE LQKLLNSKEI ANRRLNTTHA FHSSMMNGAV DGLRELLEDV
EFRSPNIAYI SSLTGDWVTE DQITSPKYWL DHMCQPVRFA DGIGKLLEDK GRVLVEVGPG
QSLGSFVKQH PSFGADNAHS VVPAMRAAFQ EEADDAYLQS MVAKLWLAGI EPIYHALYQG
ERRLKVSLPT YAFEPTRYWV EPGEMIPVNM KKADNGKVED ITHWWYKPVW RESTLKQRNA
SAAAERLLVF CDDLGYAKAA INRIQSTQTD SILVIKGDGY SRLDDNSFQI RATHPEDYDR
LIRQLQREAR LPSKIGHFFT VTDGQEPQAQ MLELGYFSLM WLVQAFGKRN LLDPLDIIVV
SSGIHEVVKG EIIDPYKSMI LGPCKGISQE APHILLRNID ICVDNSTDAI DEDLVQALRK
ELLAQPKDPI VAYRGGVRLL QDFEPFLVES IPEHDAVLKQ HGVYLITGGL GGVGLVLARH
LAKKVQAKLV LCGRSALPER EQWSQWLEAH EYNDSASVKI RKIQELESFG AEVIVLSVDA
GDEQQLKAVI DKTYETFGTL NGVVHAAGIS ESWAFRSLKD VARDDSDYQF RPKVHGVIAL
QKALADKQLD FVVLTSSVSA VLGGMTLIPY AAANIFMDNF TRIHNRTAVT RWLSVNWDTW
RLSESQHETV GKTVLEFEMS QQEGAEAFER LAYYMPSDHI VESTGNIQAR LDQWVREPFN
RVNSAEPVVK TQLYARPALS TTFIASSNEV EERVSKVWHN VLGIEEIGIH DNYFDLGGTS
LTAIQLVAEL QREFSVPVSP VVIFEAPTVH ELAKIFDDGA HKDKAANLKS AIDKRKSDRQ
RGGNESTDIA IIGVAGRFPG ANSIDDFWQN MVDGKESLTT FSDEQLLAAG VSRDEFESPE
YVRCRPIIDN ADMFDARFFG YSPMEAQVTD PQHRVLLEVA WEAMEVAGYD PLAYDGSIGV
FCGSNTNSYA ESLRRDSNTA HLLAQTEAEL ANQSDSLTTT VSFKLNLRGP SYNIQTFCST
SLVSVHVACQ NIISGECDMA LAGGISLRVP QQRGYLPVSC GTQSIDGSSR TFDANSSGTV
FGEGAGLILL KRLEDAQNDG DIIHAVIKGS ASNNDGALKA SFSAPSVDGQ AEAIAMALAN
ANIDARTIDY VEASGTATEL GDPIEVASLS RAFKSYTEDN QYCVIGSVKP NIGHPDRAAG
ILGLIKTIEA LKHEMLPGTL FFESPNPKID FANSPFMVKT ELTPWPKKRT ARRAGINSVG
SGGTNAHVIL EEAPLTRESK SGRDNELVVL SALSKKALLT ACKNLRLHLS DNPELSLSDV
AYTLAVGRRH FPVRCALVSR DVPSLLAQLE SLKLKSKQKN LIQDPGNGSV FVFGKHNNNF
ENIGFQLYRT ETMFRSEVDR CLDVFEQELD LDLCHMMQTA ELNDTPSEVL HVLKLASDFA
MARLLMSWGG VPRAMHGEGA GVIVMAVLAG VIDLNNAGKL VKFYVKSDKE QLYQTLQTMN
LDKTSFSISD ANNGTWAEAE QLKDGQFWYT QIVNENSDLS LCNGLFEQRS YTTLMFGGDD
QDIEGALNVW PEANNGSDDE AHLLSLLSQL YVGGLDLDWK SFYAEQRRNR VRLPTYPFER
RRYWVDIDYN SDRHGQSSHT AASFTDFDYC VSTPVWQQSN LVKTQITEQL RWIVLGKLEL
SLCQRVLEQL SVKGIEPICV VEGEQTEATD DNHWIVNPNQ PHALEALIKE AELGLQSVRV
LNLWPLAVTL DDEQTAKKRL LRVREALDAS QALESVFVDS CNTLQLLRVT QGAQSVTGEE
ELYAEQALLS IELALNDSEK QKQWRTLDVM LPAPQSAREL TLAEQLVSEM GASSEQSCLA
LRGKHRWVKS VDTINLELGS QDYLNDVKGR TFALVDGVND LGLTIAYQLA CAGAANIIVA
TNETLPDRSQ WDALLQADLE TDVLAQKIWQ LKVIEDNGCS VQLIVEDSKT ELGAAAIYQH
AKASDSPLHS VLLMTQGHIQ SCLESITALS KVTQDSGADE RFMIVLDEDN VEPSEHRLLL
QSYQNALAGT AACAAKVSSI ICHIGKGNLQ WEEASAAVLR IMSAHLNVAY YTANSSCVET
ETESYAAALS SRYQRPELEN EYRAPETQLQ KQLAGIWTDL LCIDAIGIDD NFFELGGHSL
LATRLFARIN RDFGLSLQLR NIFESSTIAE QADLIEVLLQ SNPVQTEGVG MMEGEI
//
