ID K2M3T3_TRYCR Unreviewed; 1025 AA.
AC K2M3T3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EKF29623.1};
GN ORFNames=MOQ_006581 {ECO:0000313|EMBL:EKF29623.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF29623.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF29623.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF29623.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF29623.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHKC01012851; EKF29623.1; -; Genomic_DNA.
DR AlphaFoldDB; K2M3T3; -.
DR EnsemblProtists; EKF29623; EKF29623; MOQ_006581.
DR OrthoDB; 138688at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR022144; DUF3676.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF12429; DUF3676; 2.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1006..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..436
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT DOMAIN 730..883
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT DOMAIN 883..936
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1025 AA; 111314 MW; 960ABD2777695727 CRC64;
MLSRVAAVMA PRTHNRRRVT GSSGRRREGR ESERQRPNMS RHLFYSAVLL LLVVMMCCGA
GAAHAAKGNQ RDAINPFKGT TSLPFANWKE LKEDGREITS LRVPGLVELG DDVFAVAEAQ
CKEKDGARSC AGIVSKHLEI SGDSMDISTS DISLFCMQLV DTAADNFWTT EMLRPTTLVL
EDSVYMLLGN YSHTKQQVQG KNERGLLLVK GTLAQENGKK KIRWNETHAV KPQPKGNSYL
LTELVGGGGS GFVMHDGALV FPMQTKKEDG ESVLLSMRLP KSGSNWELSS ETPGEGCRDP
TLVKWKQDEY DERLSMMAHC AGGYYDVYWS TSDGVNWNGH LETITRVWGN SHKRAGYGVQ
SGSTTAIIEK KEVMLITAPV YAAKEDTEGV KGRLHLWVTD GGRVYDVGPV SREDDDAAAS
SLLMKAENKE LILLYENKKK DDGSYNLVAV RLTDKVKRIK EVVKTWKDLD SHLKKCGSGS
SGTVDVRRKG MCNDTVPTEG LVGFLSGNST GTEWRDEYLG VNATVHGPAE KRRGVPNGLT
FQGSWAEWPV GNMGQTVPYY FANSKFTLVA TVSIHEVPEE SSSPIPLIGV RMNDTNSTVL
FGLSYTHDKK WLAIGEDPGD EDDVDKWEPN ETYQVALKMD TASWTVFVDQ EDIHKKRYNG
NLFVSRRISH FYIGGDSKNQ IATGGHVTVT NVMLYNDDLS DFNLNKLKTS KVTIPSLGDE
KNSTEQAVST GASVALEPKR GEDTANNHAQ LNEIDPEKQR GKNSVDEPVA AAPPSTVAAG
LSVPESATAA GSAETSRPGD SAQLFEGKTA RQAALNEGNK SMERDSEVRP KELQLAGLTD
VTDFDSSSES DDIQPRVEEE EADDRRGGSK SSLAASLSMD TDTGTGAAGA ERSLSLEAGD
RHSERSMNSD SSLTLPKSDA EPTFAEETDD SPRAEGAEIT FEDGEKVPQT ADTAPGNTTT
TPGDTKVPLE SNPTIPSDTD ISLEHAHVGE LAAMGLVGDS TVHGCLSWLL LLLLLLGLWG
TAALC
//