ID K2MLW4_TRYCR Unreviewed; 464 AA.
AC K2MLW4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
GN ORFNames=MOQ_009654 {ECO:0000313|EMBL:EKF26649.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF26649.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF26649.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF26649.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC mitochondrial processing protease (MPP), which cleaves the
CC mitochondrial sequence off newly imported precursors proteins.
CC {ECO:0000256|ARBA:ARBA00002123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF26649.1}.
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DR EMBL; AHKC01020227; EKF26649.1; -; Genomic_DNA.
DR AlphaFoldDB; K2MLW4; -.
DR EnsemblProtists; EKF26649; EKF26649; MOQ_009654.
DR OrthoDB; 7099at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 41..173
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 182..377
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 464 AA; 51863 MW; 15BAD2C05E0914B6 CRC64;
MLRCCLPRRG IVQTVKKDNY VLSRLSNGLR VLTCDDGNGI TGMGLFMLNG TKFEDEKNTG
AAAVFESLPL RSNQIFTGRE ISEALGSLGN AFKVTNNKEA MSVMLMMPRY HQKDGLELLN
AMCLHPTRDE VEFQIAKEKT GERAVLHHRD ATSVCLELVH EAGWNGKGLG QPLDPKKEDL
ENLTLEKFTA FHRTYTRPER TVLAATGVAD HKQFAAEAEL ILRFDSETTP LGAPRKHPYT
GGSRLVQKTE APESMNKFQE KNLSHVALFC QGVPMNHPDY YNISVIQTLL GGGTSFSSGG
PGKGMQTKIF REVLNREGFL HGLECITAWY SDGGLIGLYG SAPHEYVYAL LKVMIYQAAS
ICQRVSPLHL EMAKNQLRSQ LILLGEGREQ LLSDMGFNMV VHDHIITANE TMEGTKHITI
DELKRVCAEM IQRPLTFVVY GETTKMPSHE KLEETVRKTY ERLN
//
