ID   K2MYK6_TRYCR            Unreviewed;       910 AA.
AC   K2MYK6;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EKF30884.1};
GN   ORFNames=MOQ_005289 {ECO:0000313|EMBL:EKF30884.1};
OS   Trypanosoma cruzi marinkellei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF30884.1, ECO:0000313|Proteomes:UP000007350};
RN   [1] {ECO:0000313|EMBL:EKF30884.1, ECO:0000313|Proteomes:UP000007350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B7 {ECO:0000313|EMBL:EKF30884.1,
RC   ECO:0000313|Proteomes:UP000007350};
RX   PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA   Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA   Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA   Andersson B.;
RT   "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT   with the bat-restricted subspecies T. cruzi marinkellei.";
RL   BMC Genomics 13:531-531(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKF30884.1}.
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DR   EMBL; AHKC01011318; EKF30884.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2MYK6; -.
DR   EnsemblProtists; EKF30884; EKF30884; MOQ_005289.
DR   OrthoDB; 3887240at2759; -.
DR   Proteomes; UP000007350; Unassembled WGS sequence.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..910
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003861590"
FT   DOMAIN          164..483
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          74..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          756..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..770
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..841
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   910 AA;  97429 MW;  545F789E6F250E83 CRC64;
     MHCGWVAMLT VLTLFPACFS CISPSITHEE GEKKTLNTTV KFEGSERTKR THTVYTHTYF
     YMFSCVAAVK APRTHNRRGV TGSSGRRREG SESEPQRPNM SRHVFTSAVL LLLVVWMCGA
     AGSVQAQKHG AGAGHRSGGH SSGPLQRGHP VANTPAADHI FLNPHLVNVN GTLLAIAGAL
     FSGSKGSESA SMKLMAQIST DGGRNWQLYA GQGLSGDSAS SSRQVSFPSS LGTFDLYFAF
     VEGYDLRNGV RIRYDNEQGE SFLESIIHFL HTGPGKDGNL SMNSFSMSIR SPYPLQSGDI
     IGFLNDASSP ITKMEDNTLV FPVQFLTLGG DTASTILYLG SDQQHWILGK SATHAGCTNP
     SILEWEAEKI IMITSCKYGR RRVYESTDKG DTWKEALGTL SRVWSNSLAG PRLQIQSGFI
     TATIDGRKVI LLTQLEYSRH GKAEIHLWLT DTNRIYHVGL LPNTEGATSS SLLYVNDTLY
     CLYNAGFGSN SGAFFLDLTS WLHWIRRALD TWTAKDNALS RQCSPIASGA AASRGECSVP
     FPTTGLVGHL ADSFRSGEWE DEYLGVNAVV RGAAKKVPNG LTFEGKDAGA EWPVGKQWPT
     RPLHFANYGF TLAATMSIHE VPTGITPVMG LKSVGNTTLL GLSYDNNMGW SVVYGPYQKY
     FAKWELNNTY HVVLKMHDGV GSAYVDGESL FNLTLPRPSD ELRDAASHFY FGAYDEQLSS
     GKIHAKVTNV FLYNRPLSDA EIGVLNASTF SLPFTGNEQP TATSPSVEPV TAPGATEAQA
     TAQAPAPAET RPTEEVTSNG GGASTPVRST TTKPTAGEES VNQLASGTSP SAASTEGGVS
     PGENGETAGG TDGQGIHSPD GEAEAAALGL AFGSNLGNSS QRDDSVAGTV YGSRVLPMLL
     LLGLWGFAAL
//