ID K2N3T4_TRYCR Unreviewed; 267 AA.
AC K2N3T4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE RecName: Full=Topoisomerase I C-terminal domain-containing protein {ECO:0000259|Pfam:PF14370};
GN ORFNames=MOQ_006892 {ECO:0000313|EMBL:EKF29331.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF29331.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF29331.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF29331.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF29331.1}.
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DR EMBL; AHKC01013495; EKF29331.1; -; Genomic_DNA.
DR AlphaFoldDB; K2N3T4; -.
DR EnsemblProtists; EKF29331; EKF29331; MOQ_006892.
DR OrthoDB; 1123087at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.10; -; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR018521; TopoI_AS.
DR InterPro; IPR025834; TopoI_C_dom.
DR InterPro; IPR014727; TopoI_cat_a/b-sub_euk.
DR PANTHER; PTHR10290; DNA TOPOISOMERASE I; 1.
DR PANTHER; PTHR10290:SF18; DNA TOPOISOMERASE TYPE IB SMALL SUBUNIT; 1.
DR Pfam; PF14370; Topo_C_assoc; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS00176; TOPOISOMERASE_I_EUK; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 199..267
FT /note="Topoisomerase I C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14370"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 267 AA; 29057 MW; 16E422AFF1D7A962 CRC64;
MAEVTPLKAP LVTGAPTPPA SHPPTKVPVK MPYVLPKPPF APVVPVRPPA PPGRKRDGDD
GNLVALGLAD ASKRSRVEDP ERRGRAMSES SNSDSSSNSD SDDGSDSDSP SSSSESSGSS
RDDESFSSST EDSGSDEKRS ADELTLFEIA KSKGLVSERV DKKEEEEEEV EVVPVGPPPR
PPIVRSFPSN VELALQRYEE RLNREENMIR IKDDNKAVSL GTSKVNYIDP RIVCSWAKEY
NVPIGRIFSA TLQKKFPWAM GAENFSF
//
