ID K2NAD2_TRYCR Unreviewed; 932 AA.
AC K2NAD2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EKF31841.1};
DE Flags: Fragment;
GN ORFNames=MOQ_004317 {ECO:0000313|EMBL:EKF31841.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF31841.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF31841.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF31841.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF31841.1}.
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DR EMBL; AHKC01010578; EKF31841.1; -; Genomic_DNA.
DR AlphaFoldDB; K2NAD2; -.
DR EnsemblProtists; EKF31841; EKF31841; MOQ_004317.
DR OrthoDB; 3887240at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..468
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 37..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKF31841.1"
SQ SEQUENCE 932 AA; 99146 MW; C5F375C4B4AA26FE CRC64;
YYQTRIATVK IEGSKRTNST HTTQKDICML PRVAAAMASR THNRRRVTGS SGRRREGGES
ERQRPNMSRR VFTSAVLLLL VVMCCGSGTV TADEAASNEP SFEWKSITGT DVTVVSLGVP
DLLKVGSDVF VVSEAQCKKG ENTFTGVASK LLTTATTNKP VEVLNEAKDT QVLEKAGSQE
QKTDVSRPTT VVKGSDVYML VGKYSRTAVG GALESDAGEW GILLVKGEVS GDEKGVNSIH
WKNTNNISRP TFEEQHALLT QVICGGGSGV ETNDHTLVFP VEATKKNSGQ DEAAGGKNVS
LLMYTSDDSS WKLSKGMSAD GCSHLSVVEW KGKLMMMTAC DGCRRVYESG DMGDLWTEAL
GTLSCVWGNK KDEKKRIRSG FITATLGDDV NNKKNVMLVT LPVYSKKAKK EKDNENGALH
LWLTDNTHIV DIGPVSGDED EDVAASSLLY KSAGSGDNNE DKLIVLYEKK KGGAQTPSPG
MVSVLLTAQL EQVKKVLATW KEVDERVSNL CPPSGDEKDR AAGTACSDGT ITDGLVGFLS
GKFSENTWRD EYLGVNATVK GNGGTTVAAD AARVTESSDG VTFRGAWAEW PVGAQGENQL
YHFANYNFTL VATVSIDGEP EDGSIPLMGV KMNDDKGTVL LGVSYDKEKK WQGICSGKTT
MEHSSTLGPE KTQLVVSFLK NGTNCFIYFD GQRVGNAPCE LKNIGLEATE PKEISHFYIG
GDGVNADGRE GVSVTVKNVL LYNRPLDDPE IGAFNPEKAP IPPPVKTPQL TVPQSSGGEQ
EEQGRLLGRS GAGSVSTSTE STATTSSGEV GSVSQLVSGK PSDGTQRVNG GLLSDGDQRA
ESEVGDMVQG DGSAVNPEAS ASSGESGKTA GGTDGQEEDE IHPQDREANA TALSSSLGNL
SQGNNIDAGT VREIRMLPLL ILLLGLWGFA AH
//
