ID K2PEI2_TRYCR Unreviewed; 287 AA.
AC K2PEI2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Transcription elongation factor, putative {ECO:0000313|EMBL:EKF39382.1};
GN ORFNames=MOQ_000393 {ECO:0000313|EMBL:EKF39382.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF39382.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF39382.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF39382.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF39382.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHKC01001263; EKF39382.1; -; Genomic_DNA.
DR AlphaFoldDB; K2PEI2; -.
DR EnsemblProtists; EKF39382; EKF39382; MOQ_000393.
DR OrthoDB; 1383197at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd13749; Zn-ribbon_TFIIS; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 1.10.472.30; Transcription elongation factor S-II, central domain; 1.
DR InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR001222; Znf_TFIIS.
DR PANTHER; PTHR11239; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR11239:SF14; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12; 1.
DR Pfam; PF01096; TFIIS_C; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR SMART; SM00440; ZnF_C2C2; 1.
DR SUPFAM; SSF46942; Elongation factor TFIIS domain 2; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51133; ZF_TFIIS_2; 1.
PE 4: Predicted;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Elongation factor {ECO:0000313|EMBL:EKF39382.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein biosynthesis {ECO:0000313|EMBL:EKF39382.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00022478};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00472}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..287
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003865366"
FT DOMAIN 128..239
FT /note="TFIIS central"
FT /evidence="ECO:0000259|PROSITE:PS51321"
FT DOMAIN 245..285
FT /note="TFIIS-type"
FT /evidence="ECO:0000259|PROSITE:PS51133"
FT REGION 44..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 32257 MW; BAB9B9716CCDD8CE CRC64;
MFFCFLFFLL LCFTCVIVHS RACCCCCWPA RVPRRGRLGS VTTNMSEEKR DEAVGVKRPR
PVSFTPTTTP LEDSVHVTPR VSPRTPLPLA RKSVMGSPVG SFGSSTQSIT PIKPKEQPMI
GGVQGSSRVA KWSALISDAL MHGRAKEEED RINALALRIV TAIPGDRSVA ADGFRVLLVN
LRDAKNTKLR EDIIEGRLPV ELLVHMSERD LLNPEARKSQ EEEFLKRSKD TDLTEIRRAM
ATKSTLFSCP SCKARDCSWT QKQTRSADEP MTVFCICNVC DYKWRRY
//
