ID   K2PEX6_TRYCR            Unreviewed;       717 AA.
AC   K2PEX6;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EKF39487.1};
GN   ORFNames=MOQ_000284 {ECO:0000313|EMBL:EKF39487.1};
OS   Trypanosoma cruzi marinkellei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF39487.1, ECO:0000313|Proteomes:UP000007350};
RN   [1] {ECO:0000313|EMBL:EKF39487.1, ECO:0000313|Proteomes:UP000007350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B7 {ECO:0000313|EMBL:EKF39487.1,
RC   ECO:0000313|Proteomes:UP000007350};
RX   PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA   Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA   Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA   Andersson B.;
RT   "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT   with the bat-restricted subspecies T. cruzi marinkellei.";
RL   BMC Genomics 13:531-531(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKF39487.1}.
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DR   EMBL; AHKC01001174; EKF39487.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2PEX6; -.
DR   EnsemblProtists; EKF39487; EKF39487; MOQ_000284.
DR   OrthoDB; 136182at2759; -.
DR   Proteomes; UP000007350; Unassembled WGS sequence.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          109..446
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  78897 MW;  70E84936D5A0AFE5 CRC64;
     MLSRVAAVMA PRTHNRRRVT GSSGRRREGR ESERQRPNMS RRLFYSAVLP LVVVMWMCCN
     NCGAAPAEDS NSRDVQLPER VGVFLPQRTP VLPKEGAGPG EVKDSFNSPS VVSAGGVMVA
     IAEAWKEFPD PWSPTNVVED ADIVAGYINA TEPWSSIAAE ITSNKWNAHT VFAREAIKDG
     LRTAIRPTSL SKGNKLFFIV GSYLSTFDST KQDWVNHDFD ISVVTGEAMP SREGDPNKGI
     LWGTPQSLFA LITARTEHLG LNTFFGAGGS GILLENGWLV FPLTALREMV DTVFIIFSKN
     DGVDWEVATG TPPGYCTESL IFEWERKIMM IVEIVGGRKV FESVDMGNTW TEAPGILTRV
     RNRGPDSRDA SFRVGALIIA TIGRTKVMLY TQKGRLLGES KATAHYLWLT DNNRTLPLGP
     ISVDDEKEST FSNSLLFSNN MLYFLHERGD RRNDGVFLSP LKEELDRINS IVNIWVLMDI
     FFSESSIPTD GLVAFLSDSA TPNTWLDMYQ CVNATVTNAR KVPYGFKFSG PGSKGIWPVN
     RGELNRQYSF VDYNFSLVAT AIIAATPTEN TPLLGASLED LGATNFIGLS CTVDKRWETV
     LNGAKTTSSK TCEPGKEHQV AIMLQDNRGV VCVDGEIVGS SETMSTLGTR AVQVSDFYFG
     GGKGENSVTL KDVFLYNRPL SFAELRKISK TDSSCMRGSI SWLLLLGLWG FAALYGV
//