ID   K2PV43_9LACT            Unreviewed;       750 AA.
AC   K2PV43;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=ATP-dependent Clp protease, ATP-binding subunit ClpE {ECO:0000313|EMBL:EKF51316.1};
GN   ORFNames=C426_1270 {ECO:0000313|EMBL:EKF51316.1};
OS   Lactococcus garvieae DCC43.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1231377 {ECO:0000313|EMBL:EKF51316.1, ECO:0000313|Proteomes:UP000006787};
RN   [1] {ECO:0000313|EMBL:EKF51316.1, ECO:0000313|Proteomes:UP000006787}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DCC43 {ECO:0000313|EMBL:EKF51316.1,
RC   ECO:0000313|Proteomes:UP000006787};
RX   PubMed=23209230; DOI=10.1128/JB.01864-12;
RA   Gabrielsen C., Brede D.A., Hernandez P.E., Nes I.F., Diep D.B.;
RT   "Genome Sequence of the Bacteriocin-Producing Strain Lactococcus garvieae
RT   DCC43.";
RL   J. Bacteriol. 194:6976-6977(2012).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKF51316.1}.
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DR   EMBL; AMQS01000015; EKF51316.1; -; Genomic_DNA.
DR   RefSeq; WP_004260133.1; NZ_AMQS01000015.1.
DR   AlphaFoldDB; K2PV43; -.
DR   PATRIC; fig|1231377.3.peg.1267; -.
DR   eggNOG; COG0542; Bacteria.
DR   Proteomes; UP000006787; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Hydrolase {ECO:0000313|EMBL:EKF51316.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EKF51316.1}.
FT   DOMAIN          356..391
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   REGION          68..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  83734 MW;  59A6C57EB31FE6EF CRC64;
     MLCQNCKINE ATIHLYTNVN GQRKQVDLCQ NCYQIMKSGG QESLFAGATN ISNNDDPFNP
     FPDIFQALHG NDQGRPMTPP TQAGGRGPGG PQNPRGGQAP KGLLEEFGVN ITDAARRGEI
     DPVIGRDSEI TRVIEILNRR TKNNPVLIGE PGVGKTAVVE GLAQQIVDGD VPQKLQNKEV
     IRLDVVSLVQ GTGVRGQFEE RMQKLMEEIR KRDDVILFID EIHEIVGAGS AGEGNMDAGN
     ILKPALARGE LQLVGATTLN EYRIIEKDAA LERRMQPVKV DEPSVDETIT ILRGIQKRYE
     DYHHVKYSDE AILAAANLSN RYIQDRFLPD KAIDLLDEAG SKKNLTLKFV DPEDIKKRIE
     QAESQKNDAM QREDFEKAAH FRDQIAKLRE LQNHEISDTE MPNITEKDIE AIVEEKTHIP
     VGDLKEKEQT QLINLAEDLK NHVIGQDEAI DKISKAVRRS RVGLGKPNRP IGSFLFVGPT
     GVGKTELAKQ LAHELFGSAD SMIRFDMSEY MEKHSVAKLI GAPPGYVGYE EAGQLTERVR
     RNPYSLILLD EIEKAHPDVM HMFLQILDDG RLTDAQGRTV SFKDAIIIMT SNAGTGKVEA
     NVGFGAAREG RTNSVLGELD NFFSPEFMNR FDAIIEFSAL SKENLLKIVD LMLDEVNAQI
     SQNDIHLDVT QAAKEKLVDL GYDPKMGARP LRRTIQDNIE DAIADFYIEH PEYKELLADL
     VDDKIVIVNK PEEVRKEEKQ TEALEEPDEE
//