ID K2QNH8_MACPH Unreviewed; 1764 AA.
AC K2QNH8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=MPH_11380 {ECO:0000313|EMBL:EKG11491.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG11491.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG11491.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG11491.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG11491.1}.
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DR EMBL; AHHD01000468; EKG11491.1; -; Genomic_DNA.
DR STRING; 1126212.K2QNH8; -.
DR VEuPathDB; FungiDB:MPH_11380; -.
DR eggNOG; ENOG502QQJC; Eukaryota.
DR HOGENOM; CLU_002210_0_0_1; -.
DR InParanoid; K2QNH8; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 2.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1..372
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1107..1295
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1310..1587
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT DOMAIN 1712..1753
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 435..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1554..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1610..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1459..1475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1618..1637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1764 AA; 188700 MW; A6E6051120EC8001 CRC64;
MDSIKNSSTS VSAVGGYGVI SYRTFSATSS LDATTAKAAE LDGLSCVEAR LREAKRLVYL
DRQKTVLWLF EPGTSPPALD HGSLQSQQLN GLQLSSQSEG DIKAADLARL AGRHHSLSAA
QAGGQYGSTA SNARALQAAN IRAFQSNQQG SGVSAANSDA TRQHDPLSVY ESFMSAVVGS
ISYNLSRFHH MIPLNYRTFV SYPRPTTAEN PDDDDDDFTI LGGMDCLITT LDAHLSTSGT
MVISTSVSNS TEIHQLERIL TVYDAHEDFL GELVRISPCG IIARYVGHET SAVGSERDGL
GSTKRARAIQ QWKADTLRWL RMKGLVLPDM DEEGKWVRIQ LQPPQHATKD TNDPSATLCR
ECLWPAALCF FYGPIREDGD LSTADVPGHL RSHDDQDPGV MWWQGPSKQG FTDPLWQAYN
WFLGKPEREK AIEARKKARQ AQEENVQPTQ EPTMAYPSSP LYSRGSAYGD LQVVSGVYPT
PPDAVLPPNA GGHAAMDGLL MSQPNQEFIS QTGNTGTGAD GSATAEHPAP PGTTPGEHLD
PSRAMNTPAD GQDAEADNND DLFEDMDEEM FGGNDVTEAD FNFFDDGEGD FADLMDVSQP
ATFEEQQQDT SPAEAKFEDA SPVVQVSGQV HAEEEPVTYK SEITATPAVP SADIEMSEPK
DETKPGDIFQ DPEIQVDEPK GEAEEEVQIT REPSPPLGPA RIHEKLFPSV HAREADTGAK
DFAKTKAEGG AIFNTVDFNQ MMQLTDSKYA AGGQFHFPEK ANGDTMTAMN YRSANLSIRA
PPGQISRPTS SAQSLTLEST SKFIRSIVVP KHTSDDSTMD GLSEDSDSYS DISASSGSFN
EETASVAHQK DSGLLAPVHK KWGSSNAGTP MVGTPGTLQL DSGAQDTMIG ESDGIMSELP
ALSSLEPGPS DWPLARLPPP MVKVRRRPGA DTRSRRGSFS LASAASTPSS DGRSEAFTEA
PALNLKEVIN ITQMLADQVI HSTLDLMPED DDPSLLCSER QTGGCRKLAP IQKIQNAVRD
LFQQVSECDM LKYASIQDVI PEPAAANKTQ HKSVQRRNNN ADPQGSMFFT IPTPHVRLRR
GEDTWDVLPP ALSFWEPLGL SPTNGPKNIM AYCVYPSSDQ LKKPVTSFID SISMAYESCK
FGSHVRGPDI EQIATNGRVS AFVNSGEGDH WRPTAQNCLQ AVRDTCSSLG RHLSRIDFKK
HAKAEDSSTV DALVVYLVNP FSDPHNLWQL CSAFWALFQA YLPSVPSNRA VDDSKPELVL
QLVPVKYIAS FEAPVVLEPS LLTRFAREIY DRCPPREPSH DHTALSIYSA PSIQLEESLP
KSIPFRVTSE PPSDLLHENS YIHVGYAISV DGTWLTAAWT DNPGKHQATV SYCLNNRSFL
EVAREIYQTS LEIMSARRVT WRLCIARAGV MEREEQDAWQ ALVTSPCPLV IGTALVSIEP
NPSFCMTSNL PALSASQTLS SGNAGVSTPG GNTPQPGVSP DAHGFTPAAT PSDGNTSAPA
VDPANDPDAR LIDVTDESWG VILQHRLHNS NSTTEFRPAL ASGYLIKRGA DSNTDALASS
TGKSDNPDTP RGPVAVGVNL LWIGSTPGGH TPQRAAAAAA AAQAQAAAAA HAAAQAHAHT
HQSATPTPTP SAHNPNISIP LQHLEAAAAA AGGASGNGNV ASSAGATGGM GSNINSPLPS
PAGGAMGQGI GAAAAASTGG GGGGPFAANQ ARTTYDTVLK EFLVMYRGLG LLARLKGMRG
TRGGAVPWHV AAAMRGVKAL ERCV
//
