ID K2QZ13_MACPH Unreviewed; 977 AA.
AC K2QZ13;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Cytochrome P450 {ECO:0000313|EMBL:EKG15221.1};
GN ORFNames=MPH_07555 {ECO:0000313|EMBL:EKG15221.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG15221.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG15221.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG15221.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602402-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG15221.1}.
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DR EMBL; AHHD01000323; EKG15221.1; -; Genomic_DNA.
DR AlphaFoldDB; K2QZ13; -.
DR STRING; 1126212.K2QZ13; -.
DR VEuPathDB; FungiDB:MPH_07555; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_304208_0_0_1; -.
DR InParanoid; K2QZ13; -.
DR OrthoDB; 4950799at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR CDD; cd11063; CYP52; 1.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002974; Cyt_P450_E_CYP52_ascomycetes.
DR InterPro; IPR047146; Cyt_P450_E_CYP52_fungi.
DR InterPro; IPR002402; Cyt_P450_E_grp-II.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR24287; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR PANTHER; PTHR24287:SF1; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR Pfam; PF00201; UDPGT; 1.
DR PRINTS; PR00464; EP450II.
DR PRINTS; PR01239; EP450IICYP52.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|PIRSR:PIRSR602402-1};
KW Iron {ECO:0000256|PIRSR:PIRSR602402-1}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602402-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..977
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003866334"
FT TRANSMEM 677..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT BINDING 454
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602402-1"
SQ SEQUENCE 977 AA; 110128 MW; CA912A4AA0E2A46B CRC64;
MVNSGILAAA ALCLLLPLLS RLIKWHRDAQ FARANGCKAA PCDNLLTWTD LLGIGILRKL
EHHLSQKTLL EFMRKRFEEN GNTFRTRVLL DDFYWTCEPK NIQAMLALKF NDFGVGIDRY
NNFKPLMGHG IFTSDGAKWE EARALVRPNF VRNQVADLEA FEQHFQNMLT LVPRDGKTPV
DLKPLFQRMT LDSASEMLFG KSLNSLTVTD SAVASAQFAA AFKKSQTELA RRCRLGRLAD
WNISKEFLDA CGVTQRFVDD YVEEAVRLRK QSSQGEKKQD EKEPERYIFL HEIAKAIDDP
IAIRDHLLNV LIPARDSTST LLAAALFAVS KDKRVFAKLR AEVDELGGIY PSFETLKNMR
YLKWVMNETL RLWPIVPLNG RQANRDVTLP VGGGPDGQSP IHIKAGQNVG FSTYAMHRRK
DIWGPDADEF IPERWENLRP GWEYLPFNGG PRICIGQQLA LTEGGYTIVR LLQCFKDIES
LDHSEWREGL ALACSIDQPV TVRMIPWPEH GQSNVHLAVI ASLKRHYGDY VDIHLGSFES
FRNRVPAGVT FHPIFGRPLT NNFEASDAAD SLSDAVTTTP GFFGAIRGIM KMAYLLHAER
PEEYIATAES VEGLLEMLQP TLVVVDNFLD AARDAIVKKK RPYALLTPNT LKEVAAGDQG
FGLFSWPGPA AGYPYPLPWH LVIPNALLFV FFPIWLHFFD QRYALLQRHR HAAGYTGDWP
IFAGRDPDAP VLCMSHPAAD YAAKIPPGVV CCGPILRDST RVEEVDPELF AWLGRPGRQT
VLIVLGSLLK VDREYAQNVW DAFRPLLNAR NDVQVLWKLQ KGANYVIEGL ELVGEDRVRV
VEWLRPDPIA VLRTRKVVCF VNHGGSNSYH EALSTGTPQV ILSPWYDTHD FGNRAEWLGV
GRWGNKRSAP RCESRELSKC VLDVIGQTPD DEKARRYLCR AQEVAELVTH RAGDSAEGRY
GRDIAAEIIW NKAQEVL
//
