ID K2R2B7_MACPH Unreviewed; 455 AA.
AC K2R2B7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=MPH_06365 {ECO:0000313|EMBL:EKG16396.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG16396.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG16396.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG16396.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG16396.1}.
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DR EMBL; AHHD01000269; EKG16396.1; -; Genomic_DNA.
DR AlphaFoldDB; K2R2B7; -.
DR STRING; 1126212.K2R2B7; -.
DR VEuPathDB; FungiDB:MPH_06365; -.
DR eggNOG; KOG1684; Eukaryota.
DR HOGENOM; CLU_009834_22_0_1; -.
DR InParanoid; K2R2B7; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129}.
FT DOMAIN 35..382
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 50964 MW; 475B7C5010C3B548 CRC64;
MQSSRQYASQ SEADLARPQP GDEPDDVLFD KVYGVRTIEL NRPKKLNSLN GSMARKIIPR
LREWSQSQLA NVIIIKGNGR AFCAGGDVAA LAKLNTQGKE GQQQSSDYFG LEYKLDHLIA
TYSKPYVAFM DGITMGGGVG LSVHAPFRIA TENTIFAMPE TTIGFFPDVG ASFFLPRMDG
QMGTYLALTS EQLKGVDVFY HGIATHYIHS SSLPELEARL AELTFKDYAS LQERHAIINA
TIEEFVTGLP APRAEISGQL RAAVDECFKP ENESIAAILD SLTVLKESSN TTLSPWAAKT
IDTMQQRSPT SVLVALQQLR VSRNWGIADT FHHEYNIASR FMAHPDFVEG VQARLVRRQK
ERPNWEPATF DQVDPKEIDA FFQGRQSLEL LENGPEANYK EYPHAWLGLP KENFILQKAQ
RLGSDREVIQ FFVKEYKGKA GVKEKVQEVL ERSRL
//
