ID K2RFE4_MACPH Unreviewed; 783 AA.
AC K2RFE4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=AMP-dependent synthetase/ligase {ECO:0000313|EMBL:EKG11557.1};
GN ORFNames=MPH_11050 {ECO:0000313|EMBL:EKG11557.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG11557.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG11557.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG11557.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG11557.1}.
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DR EMBL; AHHD01000467; EKG11557.1; -; Genomic_DNA.
DR AlphaFoldDB; K2RFE4; -.
DR STRING; 1126212.K2RFE4; -.
DR VEuPathDB; FungiDB:MPH_11050; -.
DR eggNOG; KOG1176; Eukaryota.
DR eggNOG; KOG1680; Eukaryota.
DR HOGENOM; CLU_356751_0_0_1; -.
DR InParanoid; K2RFE4; -.
DR OrthoDB; 2599041at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EKG11557.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 286..637
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 688..766
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 783 AA; 85109 MW; 5CE87D9B3FE44FA4 CRC64;
MADSPILVSF PGPYVVKITL NRPSALNAIN ADLLDGLTSA LRSHQDARVI LLEGAGDRSF
CAGEDLKQTL APRTGSAKEL REAFSKLQDI TRLTSSSQAV VVVSVQGFAI GGGAEIALAA
DFLIGGPNAK FRFPEVTLGH AVTGGISLRL TQLVGLLKAK ELLITGRWVD AGEALKLGML
SEVAEDPKRR AEELAVQLAA LPAIAMASSK MQLERVVFPN LEACLQDEVN VASYCFAQSD
ADQAFANFAT RKAPASKKTT LGVTTADGVS DETRDRPIRD INSALEYAVT AFPNRTFLRM
SGADISFSQC NEAIRKLAGG LQRAGVQCND RVLVMMRNSV EMVYSWLAAN RLGAVYVPVN
VELKSITLRR VVEAANPKMA VVDAEMLPEL QALGVVHSDS IYVKGGDGAS VNAFSRLMDA
GEAIDTHVKV MPATTAALLY TSGTSGRSKP CVLSHEYFIL QAKGLMEGCL LRQDDVLYCP
FPLFHADATA LTVVPAILLG AVAALSARFS PSKFWEIRGM GATVYDFMGA TLALTYKQPP
SPRDCDHKVR LAWGVPIPHF AKDYEERFGH PLVTLYGSVE AGLPIIQQGE LPYGSCGRLR
RGFQLRIAND MDEEVPPNTL GHLLLRSDQP NGFFDGYFND AFSTASAFRS LWLHTGDLAK
VDEAGNVYFL GRAKDVIRRR GENVNASEVE EEFLQHPDVV IAAAYGIPSQ FGEGTEEDIK
VVVQLREGSV IDERGLWEWA RAHMAWFQVP DVLERVEEIR GTPTGKIEKY GLRVEGGVRF
DRK
//
