ID   K2RHK7_MACPH            Unreviewed;       741 AA.
AC   K2RHK7;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=alcohol dehydrogenase {ECO:0000256|ARBA:ARBA00013190};
DE            EC=1.1.1.1 {ECO:0000256|ARBA:ARBA00013190};
GN   ORFNames=MPH_08810 {ECO:0000313|EMBL:EKG14068.1};
OS   Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC   Macrophomina.
OX   NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG14068.1, ECO:0000313|Proteomes:UP000007129};
RN   [1] {ECO:0000313|EMBL:EKG14068.1, ECO:0000313|Proteomes:UP000007129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MS6 {ECO:0000313|EMBL:EKG14068.1,
RC   ECO:0000313|Proteomes:UP000007129};
RX   PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA   Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA   Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA   Saito J.A., Alam M.;
RT   "Tools to kill: Genome of one of the most destructive plant pathogenic
RT   fungi Macrophomina phaseolina.";
RL   BMC Genomics 13:493-493(2012).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKG14068.1}.
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DR   EMBL; AHHD01000375; EKG14068.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2RHK7; -.
DR   STRING; 1126212.K2RHK7; -.
DR   VEuPathDB; FungiDB:MPH_08810; -.
DR   eggNOG; KOG0023; Eukaryota.
DR   HOGENOM; CLU_374705_0_0_1; -.
DR   InParanoid; K2RHK7; -.
DR   OrthoDB; 5295198at2759; -.
DR   Proteomes; UP000007129; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08297; CAD3; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR   PANTHER; PTHR42940:SF3; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          34..379
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   REGION          641..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          712..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..680
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   741 AA;  79198 MW;  2348463D118318F7 CRC64;
     MATVLPHLIS GATNEQKKKK HNLDVRIPTT QKAAVKDGLT APLKEVPVPE LKAGQILVKI
     NWTGLCHSDI GFLRDYWPTS GFPELVMKMA GGVCGHEGAG DVVAVAPDVA AEELWHVGDR
     AGVKWCASVC RRCEFCTNGA DELHCPKQLN SGLTTPGTFQ QYVATDARYA TRLPDEVSDE
     EAGPLMCGGV TAYVACKRSG VKPGQWIAHM GAGGGLGHLG LQYAKVMGMR SIAIDVGSEK
     EQLCKKLGAE VYIDAAKCED LVAEVMKVTT YGAHGVIVFA PTKQCYDTAP YMLRPGGTMV
     PVGFPKDPTV VAGAPPSFLS MRKLNIAGSV TGTLKEVEEM LDFTARGLVH PILVKGKLSE
     LDKYIDLVAE GKLSGRAVLN VADVLEGAGN SSRCRTAAVT SETLQKAGML AKGSKKSARG
     FLPAVTPCGN GESVINTTTR ASIDIFNFKG TRTDENEHGS TRLDLATARN ASEARTPFLN
     SATARTTTPT GINRTAAAMQ RSTDGVLPPP RLAGTIFSTG NVIDHNQSAG AKTTGITATE
     QDMSNLGIAE MTPIAANISR VSDVQSVEVT ATEVDNVKDE TPIPQKRTQR ARVGKPVTLN
     RHILRSATQT AAAAAAAAEC PPKPARFLIF ISRAKNASIA SNGTHSNVDM GDVKDENEDD
     KAQDVDAESE DVRKEESAAS SPARPLHISM MRCAGSLRKH YRRVYGRCIS NEVEHDFSEE
     EEGEEGEEKR ARKKHKTRGR L
//