ID K2RWM6_MACPH Unreviewed; 1041 AA.
AC K2RWM6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Ribonuclease II/R {ECO:0000313|EMBL:EKG19168.1};
GN ORFNames=MPH_03538 {ECO:0000313|EMBL:EKG19168.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG19168.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG19168.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG19168.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG19168.1}.
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DR EMBL; AHHD01000165; EKG19168.1; -; Genomic_DNA.
DR AlphaFoldDB; K2RWM6; -.
DR STRING; 1126212.K2RWM6; -.
DR VEuPathDB; FungiDB:MPH_03538; -.
DR eggNOG; KOG2102; Eukaryota.
DR HOGENOM; CLU_002333_5_0_1; -.
DR InParanoid; K2RWM6; -.
DR OrthoDB; 945235at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 947..1041
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT COILED 400..427
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1041 AA; 117401 MW; D67FBC25A84DD762 CRC64;
MHGRLGTQTD ANTLRSRKLR PRPALHNLTR SACVIAGVTV CTALSTQLVL LLVAMTSLKR
SFAADPAGPN LASKVYVRST RSGKVQKIVR ELYLRQDIPC SSKLCSACLD SAPKDYNGKV
APFVLSERPA GTKVFPNGHY LIPDTNAFLT GMDLFEVDTA FHDVVVLQTV LEEVKNQSTP
LYNRLISLTK NADKHFYVFF NDFRLETYVT RNEGETINDR NDRAVREAVK WYGQHLQEAL
KLRKGTVKCP AVVMLSDDRE NLRKAKADGL QALSLSEYVS SLPNADQLLD MVAEGQEQRE
TKASQGQFFY PEYYSFSKMM TGVKNGTLHQ GIFNVSPYNY LEGSVHVPAF EKSLLVLGRE
NSNRAVSGDV VVVEVLPKEQ WKAPSSKIIE EETLNKNENA DVEEGEAVIT ERERRALQEE
VKRAQGKSVE GQPQPTARVV GIVKRNWRQY VGHVDRDSVK STAKQSRTQQ TVFLIPMDKR
IPKIRVRTRQ AGEMLGKRIL VTIDSWNRES RYPMGHFVRS LGELESKGAE TEALLLEYDV
QYRPFPKAVL DCLPPEGHDW RVPESKDDPG WKGRRDLRDL LVCSIDPPGC VDIDDALHAQ
PLPNGNFQVG VHIADVSHFV KPNNAMDKEA SMRGTTVYLV DKRIDMLPML LGTDLCSLKP
YVERYAFSVL WEITPDAEIV SADFSKSVIR SREAFSYEQA QLRIDDQSQQ DELTQGMRTL
LMLSKKLRQK RYDAGALNLA SPEVKVQTES ETSDPIDVQT KRLLDTNSLV EEFMLLANIT
VARKNYEAFP QTALLRRHAA PPKNNFEELA NQLKVKKGLE LRVDSSKALA DSLDTCLDPN
EPFFNTLVRI MATRCMMSAE YFCAGTQAYP EFRHYGLASE IYTHFTSPIR RYADLEAHRQ
LAAAIEYEPL DSSLHSKSKL EGICKNINVR HRNAQFAGRA SIEYYVGQAL KGRVIDEEGF
VMRIFTNGIV VFVPRFGIEG LIRLRDLASP EPNAEFDAEN YVLTVSGSRD VRLELFQKVT
VRISDEQEES TGKRKIKLGL L
//
