ID K2RY74_MACPH Unreviewed; 973 AA.
AC K2RY74;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN ORFNames=MPH_05101 {ECO:0000313|EMBL:EKG17652.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG17652.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG17652.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG17652.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000256|ARBA:ARBA00002558}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG17652.1}.
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DR EMBL; AHHD01000229; EKG17652.1; -; Genomic_DNA.
DR AlphaFoldDB; K2RY74; -.
DR STRING; 1126212.K2RY74; -.
DR VEuPathDB; FungiDB:MPH_05101; -.
DR eggNOG; KOG1421; Eukaryota.
DR HOGENOM; CLU_003212_0_0_1; -.
DR InParanoid; K2RY74; -.
DR OrthoDB; 1779375at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.40.10.120; -; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022825};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 253..331
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT DOMAIN 826..907
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
SQ SEQUENCE 973 AA; 108298 MW; ADB8A368C41BAF28 CRC64;
MDLDYDSDDM RSVTHIGASG DTVEWQRTIE KVVKNVVSIH FCQTAAFDTD SALASEATGF
VVDAQRGYIL TNRHVVGAGP FWGYVIFDNH EEVDVHPVYR DPVHDFGILK YDPKAVKYMD
LSALELRPDL ARVGEEIRVV GNDAGEKLSI LSGVISRLDR NAPEYGEGYS DFNTNYIQAA
AAASGGSSGS PVVNRDGAAV ALQAGGRADG AATDYFLPLD RPLRALQCIR KGEPVTRGTI
QTQWILKPFD ECRRLGLTSN WEDAMRKQFP KETCLLVAEV ILPNGPADAK IQEGDVLIKV
NGEFLTQFVR LDDILDSSVG GKINLLIQRQ GVDMEVEVSV GDLHEITPDR FVSAAGASFH
ELSYQQARLY AISTKGMGVF VCEASGTFRF EGSESGWLVQ SIDHKETPDL DTFVQVMKEI
PDRSRVVVTY KHIRDLHTLN TSVLTIDRHW HDKMKLAVRN DVTGLWDISD LADRIPPKPR
EPQRANFIRM DQAQHPQAVD IVRSFVRISS TMPLKLDGFP RSRKVGYGLV VDAKKGLVLV
SRAIVPYDLC DIQITIADSI VVEGKPVFLH PLQNYAIVKY DPALVQAPVK TAKLSDKFIK
QGEDTIFFGF NQNLRPVVAK TVVTDITTVA IPASAATPRY RAINLDAVTV DTNLAGQCGS
GVLIAEDGTV QAIWLTYLGE RSSHSGKDME YHLGLSTPMV EPVLRQLRNG VQPKLRILNV
EMHTVQMDKA RVMGVSEEWI QRLEHEDPER HQLFMVRKVD SGHEGGLLEG DVILSFNGKL
ITRVSDLDIM YDNEFLDAVI IRKQKEISIK VPTVPTEDLE TDRAVLFCGA ILHRPHHAVR
QQISKVHSDI YVSGRMRGSP ACAYGLAPTN FLTHVNGVST PDLSSFLREV KKIPDNTYFR
LKVMTFDNVP WVATMKKNEH YFPTIEFVKD EAEELRWKRI VHECDEGGAK EMMSAVTDTA
GAEEGAEIPE RLK
//
