ID K2S6H8_MACPH Unreviewed; 1167 AA.
AC K2S6H8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Oxysterol-binding protein {ECO:0000313|EMBL:EKG12415.1};
GN ORFNames=MPH_10532 {ECO:0000313|EMBL:EKG12415.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG12415.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG12415.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG12415.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG12415.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHHD01000451; EKG12415.1; -; Genomic_DNA.
DR AlphaFoldDB; K2S6H8; -.
DR SMR; K2S6H8; -.
DR STRING; 1126212.K2S6H8; -.
DR VEuPathDB; FungiDB:MPH_10532; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_001040_1_1_1; -.
DR InParanoid; K2S6H8; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13292; PH_Osh1p_Osh2p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF205; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 118..150
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 225..257
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 315..410
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 617..651
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 414..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 129316 MW; 5666F53EB96FF7B1 CRC64;
MSNSNAPSSD ALSPPYAAQS PSSPTTKAAS IEQSVRLFRI FEALRNGDTA AISKAIREEA
STQSGARQST SSIASLSGVR LEGTTILHLA IQCAELPVIE FILSNVGAGI DLNGRDRDGN
TPLHLAAQLG RAPVVRMLLE QNGINDSLTN YQGQTPLDLA RTPDIFQQLQ LTRSIFIDTN
VKKIQELALK EDYKGLEAVL TDARVQTTLD VNGPELATDP ATVETGGTLL HEAARKKDTQ
LCQLLLLNGA DPFRRDRKGK LPHEVTKDDK TKAILKKSPA AAAAQRGIQE KTILGAAAQA
AGPASAEVAL GSKESREMKG YLKKWTNYTG GYKLRWFVLE DGVLSYYKHQ DDIGSACRGA
INMRIAKLHM DPQDKLRFEI HGKSSVKYHL KANHQVEAKR WFWALNNAIQ WSKDEAREEE
KRQTRETEAL RQAKVEQATK EGDTGSTASS RPNGRNSVFS PASSGTLVPP AGSRTGASTG
EEDELGNSTY DASLGGEEVS RFESRTGKSI GDLDDEDDYG DDVSSDKAQP VSKDAFNITA
QSVKLQLDLL AQVSAALQAE KAKNPSMPIS DPAATQAITS YEGAVSSLKG LVGDLFRIAR
DRDAYWQYRL DREANVRRMW EESMAKVAKE QEELENRIGE SEDKRKRTKK ALRDALQGLQ
SGETAQAKNA IAETVAIHEE DEPVGADETV ARRKDSTTNR PNLAELAELS DSESDDDEFF
DAIQEGEVQV VEELPVTSPL PQETSEKPPT MDLQEAKAAE IVPSFIGYED PVRTRLKLDD
DNRPKISLWG ILKSMIGKDM TKMTLPVSFN EPTSLLQRVA EDMEYVDLLD TAAERHDSCE
RMVYVAAFAA SEYASTIGRV AKPFNPLLGE TFEYCRPDKG FRFFVEQVSH HPPIGAAWAE
SAKWDYYGES AVKSKFYGKS FDINPLGTWF LRLRPASGGE ELYTWKKVTS SVIGIITGNP
TVDNYGLMEI KNHTTGEVCL LDFKPRGWKA SSAYQVAGKV VAADGQTRWS IGGRWNDKIY
ARLTPGYEDS DNVGGKDKQA TLVWQCHERP TGIPFNLTPF VLTLNALPDR LKPILAPTDT
RLRPDQRAME DGEYDFAATE KNRVEEKQRA KRREREANGE EFHPHWFSKE VDEVTGEEYW
KFNGEYWKMR EKVAKGEGQW EGCEDIF
//
