ID K2SJH8_MACPH Unreviewed; 1141 AA.
AC K2SJH8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Ras-like guanine nucleotide exchange factor {ECO:0000313|EMBL:EKG16965.1};
GN ORFNames=MPH_05790 {ECO:0000313|EMBL:EKG16965.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG16965.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG16965.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG16965.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG16965.1}.
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DR EMBL; AHHD01000258; EKG16965.1; -; Genomic_DNA.
DR AlphaFoldDB; K2SJH8; -.
DR STRING; 1126212.K2SJH8; -.
DR VEuPathDB; FungiDB:MPH_05790; -.
DR eggNOG; KOG2070; Eukaryota.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002632_0_0_1; -.
DR InParanoid; K2SJH8; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 718..851
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 887..1124
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 70..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 127167 MW; A4DF09AE8645BBF5 CRC64;
MNGYSGTLAP PGGLYVRALY DYDADDRTSL SFRQGDIIQV ITQLESGWWD GVINGVRGWF
PSNYCAVVSP PKDDTREAES SADEGDGSGT VDGSQDLGSY SEASDTDDDG GHTQLPLEGT
EPDKEEEAAF WIPQATPDGR LFYFNTLTGV STMELPLETP SSLAENGPRD RTNVNMPESS
RPPPELMAGG WHMYNGDTDD ENSASDVEGP SGMGGSHSSL QRRRSLASNG ISPATSMDSM
SNASGLTRSR SDLHEHANNT SFSGLGPPLG STMSSYANNS IGAPLTSAVS RQFFDDAQAV
PLTWNRMVED MRRSVERYRQ AINNSDRSEF VKRAEDISDH LRLLLAAGSG TTDNHSGNPS
IISTNKALYP HFRETMSRFS KLVLSSHIAA ADWPPADSYS KCLKEADGVL NGVYGFVEVA
RQQRGEDIPR LIPGFVVGSY NGGNWQNNGL STHDPMNPMS FIDQDDFEEP STRLDDKLVE
RLDDLKRLIV SSIRKLDERL VVEEKVITHS VHQKLGERVC KAAAKVLEVY RPWIATVESI
NLAPIGSTFQ NPQIADFSVA KQKVYDMISE LILACQAVAA PLGDEWAENR GDSLEERLNH
VRQVSRDLES NTAKLYFSLQ LLSDLMPVED SPSSIDVKRN TEMDLYNNYQ RKPSTQFNRS
PLGDDPLDPI HSGGNNSKLK KFFGEVPAPV LPQAVPEEIP EFLQLDHEGE ISYDLKVAPP
QLKGGTLAGL VEQLTRHDRL DSPFNNTFLL TYRSFTTANE LFDMLVKRWS IQPPPGLSRE
DYQLWVDKKQ KPIRFRVVNI LKSWFDNYWM EGNDDEAQAL IQRVYAFAKD HVATTSTPGA
GPLMTAVEQR ARGQDAPTKR LVLTLNTSTP QPILPKHMKK LKFLDIDATE FARQLTIIES
RLYGKIKPTE CLNKTWQKKL APGEADPAQN VKALILHSNQ LTNWVAQMIL TQSDVKRRVV
VIKHFVSVAD KCRTLNNFST LTSIISALGT APIHRLSRTW TSVNARTMTT LENMRKLMGS
TKNFAEYRDT LHKANPPCIP FFGVYLTDLT FIEDGIPSLI KKTNLINFAK RAKTAEVIRD
IQQYQNVPYP LQPVPELQDY ILTNMQSAGD VHEMYDMSLA VEPREREDEK IARLLSESGF
L
//
