ID   K3W0G1_FUSPC            Unreviewed;       789 AA.
AC   K3W0G1;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=3-hydroxyacyl-CoA dehydrogenase C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=FPSE_05744 {ECO:0000313|EMBL:EKJ74090.1};
OS   Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=1028729 {ECO:0000313|EMBL:EKJ74090.1, ECO:0000313|Proteomes:UP000007978};
RN   [1] {ECO:0000313|EMBL:EKJ74090.1, ECO:0000313|Proteomes:UP000007978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CS3096 {ECO:0000313|EMBL:EKJ74090.1,
RC   ECO:0000313|Proteomes:UP000007978};
RX   PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA   Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA   Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT   "Comparative pathogenomics reveals horizontally acquired novel virulence
RT   genes in fungi infecting cereal hosts.";
RL   PLoS Pathog. 8:E1002952-E1002952(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKJ74090.1}.
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DR   EMBL; AFNW01000120; EKJ74090.1; -; Genomic_DNA.
DR   RefSeq; XP_009257137.1; XM_009258862.1.
DR   AlphaFoldDB; K3W0G1; -.
DR   EnsemblFungi; EKJ74090; EKJ74090; FPSE_05744.
DR   GeneID; 20364362; -.
DR   KEGG; fpu:FPSE_05744; -.
DR   eggNOG; KOG2304; Eukaryota.
DR   HOGENOM; CLU_017201_2_0_1; -.
DR   OrthoDB; 1952864at2759; -.
DR   Proteomes; UP000007978; Chromosome 1.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007978}.
FT   DOMAIN          531..685
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          690..786
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   789 AA;  88171 MW;  8A5EFBA175C2D6ED CRC64;
     MSAAGLVLPA KKIQETHRRP AHAVGTGIKR VPFRANTSGA KRKSRRRTTS RPLSDTSSTH
     ASHVAEAPEP HALRQARVFE ADIAISGDTL TGSAVLESVS PPRYTNPSRG YVVNDSMEDL
     DTTWLDTLYR EGFEVVFGSW MGSYSCPFLF GHTLADKYVS ISDLCRHLDG CIVDSGNSQV
     AGRGEEAELS LQSTICAFAA RWLPVTSAVE SSENHCNLVQ SLWRHARRDM LRIINRPSYR
     SMLSLLLFAL TPIPEGISEE EETDGISGQA CVHAALQQIQ NLRAHQRNLQ FSGSKVSPSL
     RSETVTTPES IESSGFINAE STVYWAALTF DTSASLTLNC RPLLSSGLFG FESELPWRLV
     RTCAKMFDEN ARQWKQASAD MTDERANQII AAGASWKLLG WKLTAIFKEA LRDGHEEPEV
     RKAYFAVVDS IKQFGIVYRP HLDECHKRMP FLGQKTKLRW FSLMLHYHLG ILMLVDIIQA
     TDRQDLLPDI TDISIDAENT IMNTLAFGLH NTFTLKRPNS DSQNGSRSWS STGSDVHLVD
     SQEAQLQASL EAIDEFRRSC NKENASWGKI ITHSRDTLSE ALQAAWLVVE CVPERLDLKQ
     KIIVELDSIA PKETIIASNS SSYSCSEILK GLDLNHESRF LSAHSYWPPE VPEIEIMGHE
     TTNSSHIDFM IKQCKVHGFS PFHVKKPSMG YIYNRIWAAI KREALLTAAE GVATPEEIDG
     IFKGVLKTPK GPFEQMDLVG LDVVMDIEQH YADERGNIPS EPREYLQKFL DEGNLGIKSG
     RGFYDYTKR
//