ID K3W4N9_MOUSE Unreviewed; 635 AA.
AC K3W4N9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) {ECO:0000313|Ensembl:ENSMUSP00000070711.8};
GN Name=Mpp4 {ECO:0000313|Ensembl:ENSMUSP00000070711.8,
GN ECO:0000313|MGI:MGI:2386681};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000070711.8, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000070711.8, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000070711.8,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000070711.8}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000070711.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; K3W4N9; -.
DR SMR; K3W4N9; -.
DR ProteomicsDB; 361544; -.
DR Antibodypedia; 34145; 62 antibodies from 15 providers.
DR Ensembl; ENSMUST00000066374.14; ENSMUSP00000070711.8; ENSMUSG00000079550.10.
DR AGR; MGI:2386681; -.
DR MGI; MGI:2386681; Mpp4.
DR VEuPathDB; HostDB:ENSMUSG00000079550; -.
DR GeneTree; ENSGT00940000156444; -.
DR ChiTaRS; Mpp4; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000079550; Expressed in retinal neural layer and 69 other cell types or tissues.
DR ExpressionAtlas; K3W4N9; baseline and differential.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12034; SH3_MPP4; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR035600; MPP4_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF34; MAGUK P55 SUBFAMILY MEMBER 4; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|MaxQB:K3W4N9,
KW ECO:0007829|ProteomicsDB:K3W4N9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 23..79
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 86..136
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 153..234
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 241..311
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 426..615
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 569..620
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 635 AA; 72072 MW; 82E11EA6309C6926 CRC64;
MRQSDRGAEL TNEDRALPTP PDPENGLSGI LRLLLQELSL FYSRDVNGLC LLYDLLHSPW
LQALLKVYDC LQRFKEKKLV PDTTHAQILA CEVLELLPKA SGSPEIQELR QVLQAPHCKA
LLSAHDTVAQ KDFEPLLPPL PDNIPDSEEA MRIVCLVKNQ QPLGATIKRH EITGDILVAR
VIHGGLVERS GLLYAGDKLV EVNGVSVEGL DPEQVIHILA MSCGTIMFKV IPVSAPPVSS
QKMVYVRAMI DYWPQEDPDI PCMDAGLPFL KGDILQIVDQ NDALWWQARK ISDLTICAGL
IPSNHLLKRK QREFWWSQPY QPHTCLKSTR ACTFENEDSM KIDEKCVEAE EIIYEGVRLL
ETKDEFVGDG QKFFIAGFRR SMRLCRRKSH FSQLHASLCC SCSCYSAVGA PYEEVVRYQR
QPADKHRLIV LVGPSGVGVN ELRRQLIGCN PSCFQSAVPH TTRFPKSYEM DGREYHYVSR
ETFESLMYGH KMLEYGEYKG HLYGTSVNAV HAVLDEGKIC IMDLEPQDIQ SARTRDLKPY
VIFIKPPNTS SMRHSRKNAK ITTDYYVDMK FKDEDLQEME ELAQKMESQF GQFFDHVIVN
DNLQDACGQL LSAIQKAQEE LQWVPEAWVS PDTES
//
