ID K3WCD0_GLOUD Unreviewed; 1110 AA.
AC K3WCD0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=NFACT RNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Globisporangium ultimum (strain ATCC 200006 / CBS 805.95 / DAOM BR144)
OS (Pythium ultimum).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Pythiales; Pythiaceae;
OC Globisporangium.
OX NCBI_TaxID=431595 {ECO:0000313|EnsemblProtists:PYU1_T002621, ECO:0000313|Proteomes:UP000019132};
RN [1] {ECO:0000313|Proteomes:UP000019132}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DAOM:BR144 {ECO:0000313|Proteomes:UP000019132};
RX PubMed=20626842; DOI=10.1186/gb-2010-11-7-r73;
RA Levesque C.A., Brouwer H., Cano L., Hamilton J.P., Holt C., Huitema E.,
RA Raffaele S., Robideau G.P., Thines M., Win J., Zerillo M.M., Beakes G.W.,
RA Boore J.L., Busam D., Dumas B., Ferriera S., Fuerstenberg S.I.,
RA Gachon C.M., Gaulin E., Govers F., Grenville-Briggs L., Horner N.,
RA Hostetler J., Jiang R.H., Johnson J., Krajaejun T., Lin H., Meijer H.J.,
RA Moore B., Morris P., Phuntmart V., Puiu D., Shetty J., Stajich J.E.,
RA Tripathy S., Wawra S., van West P., Whitty B.R., Coutinho P.M.,
RA Henrissat B., Martin F., Thomas P.D., Tyler B.M., De Vries R.P., Kamoun S.,
RA Yandell M., Tisserat N., Buell C.R.;
RT "Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals
RT original pathogenicity mechanisms and effector repertoire.";
RL Genome Biol. 11:R73-R73(2010).
RN [2] {ECO:0000313|Proteomes:UP000019132}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM:BR144 {ECO:0000313|Proteomes:UP000019132};
RA Buell R., Hamilton J., Hostetler J.;
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblProtists:PYU1_T002621}
RP IDENTIFICATION.
RC STRAIN=DAOM BR144 {ECO:0000313|EnsemblProtists:PYU1_T002621};
RG EnsemblProtists;
RL Submitted (NOV-2014) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR AlphaFoldDB; K3WCD0; -.
DR STRING; 431595.K3WCD0; -.
DR EnsemblFungi; PYU1_T002621; PYU1_T002621-p1; PYU1_G002618.
DR EnsemblProtists; PYU1_T002621; PYU1_T002621; PYU1_G002618.
DR VEuPathDB; FungiDB:PYU1_G002618; -.
DR eggNOG; KOG2030; Eukaryota.
DR HOGENOM; CLU_003612_1_1_1; -.
DR InParanoid; K3WCD0; -.
DR OMA; MFLEFFA; -.
DR Proteomes; UP000019132; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000019132}.
FT DOMAIN 568..685
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 961..1082
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 470..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..489
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..774
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..800
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..925
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 123774 MW; F4794F75185D69A3 CRC64;
MKKTRMSIDD IHAMVGSIRK NVLNMRVTNI YDLQSASGDK SKTYIFKLHQ PPYPKVFLLL
ESGIRFHTSK YARDASSSSA TLPSQFTMKL RKHLRGKRLV ALQQLEGDRV VDLTFGSDQL
QCHLILELYA SGNIILTDES YNILSLLRTH KFDENVKMAV KQVYPIEVLE KKSPSDSIQT
VPQLTEFVTK WFADLEVKAA TMGGGASKTK KKVQTLKQLL LMKESSFGGL GPVIVEHCVV
SADLQPGLKI KNAAEFEAIG EDRLTKLVKE LQGGWKLLEK LQAEQNTAVV DTTEDGTPLD
VPEDTAPKEK CGFIIMKEQV NESLPEQYEE FTPYLYAQHR NKKIQSFDTF DEAVDEYFSR
FETETAEVAK QAAQLAAEAK LAKLKKNQKT QIDQLLEVQD KSLKHARLIE ENQQDVENVL
LVIRSALASG MDWRGLEELV RFEQKNGNPV ASLIHELDLA HNRVSILLCD SDNDNDNDDD
EEDEDEDEKD QQDKQAHVIW IDLSLSALAN AREIYTKKKK AGEKVQKATE ATQRAIFAAE
KSTTKTLQKQ QMKRNTIYER RKIMWFEKFH WFLTNEKYLV IAGKDAHQNE LLVKRYLRKG
DVYVHADLHG AATCVVRNRA AVAGEKTIPP IPVGTLEQAG CMSVCRSNAW TSQVIAGAYW
VHADQVSKTA PAGEYLTTGS FMIRGKKNYI QPSRLEMGLA IVFRVDESSL ANHEGDDGDE
KAPPAREYDA DADVDEDVTQ QEETADKPEE TQDTVTQDDD DEDKVDDVEE ASTDAVEESV
PPQATEEDNE AEEARDEDEE ATNDSAAPAE RPGKKRLSAK ERRDLKKGKL PGTLAPVPAD
ASGNKASALK EKTAAASSKA NDAAKNVRGK KGKLKKLKKK YADQDDEDRR LRMELLGHTL
PDEDAGDEEE GSGDTNDDDD DNDSSKNGND GEKKPKGADE DEIRRLREKK EKFLKEQEEE
AEGADFFDTF TGSPFPNDLV LYAMPMCAPY ASLQKYKYKV KLLPGAQKKG KAAKQAMEYF
FSSNMKFEKD AAKQHAAHKA QAENGADETT PDVDPLVVQR ELMRCIPENE LVNCMVGPVK
ISAPGIYGSS ASGKKGGGGG TKKKLSKGKK
//
