ID K3XEX2_SETIT Unreviewed; 736 AA.
AC K3XEX2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Subtilisin-like protease {ECO:0008006|Google:ProtNLM};
GN Name=101782848 {ECO:0000313|EnsemblPlants:KQL07320};
GN ORFNames=SETIT_5G347200v2 {ECO:0000313|EMBL:RCV27717.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV27717.1};
RN [1] {ECO:0000313|EMBL:RCV27717.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL07320,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV27717.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV27717.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV27717.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL07320}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL07320};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; AGNK02003334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003532; RCV27717.1; -; Genomic_DNA.
DR RefSeq; XP_004970244.1; XM_004970187.3.
DR AlphaFoldDB; K3XEX2; -.
DR EnsemblPlants; KQL07320; KQL07320; SETIT_000439mg.
DR GeneID; 101782848; -.
DR Gramene; KQL07320; KQL07320; SETIT_000439mg.
DR KEGG; sita:101782848; -.
DR eggNOG; ENOG502R8FD; Eukaryota.
DR HOGENOM; CLU_000625_4_2_1; -.
DR InParanoid; K3XEX2; -.
DR OMA; WEEENGV; -.
DR OrthoDB; 11910at2759; -.
DR Proteomes; UP000004995; Chromosome V.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR InterPro; IPR041469; Subtilisin-like_FN3.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR PANTHER; PTHR10795:SF632; SUBTILISIN-LIKE PROTEASE; 1.
DR Pfam; PF17766; fn3_6; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..736
FT /note="Subtilisin-like protease"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010125660"
FT DOMAIN 31..108
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 134..563
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 630..724
FT /note="Subtilisin-like protease fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF17766"
FT ACT_SITE 143
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 212
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 524
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 736 AA; 79945 MW; 9F7D2370F0340567 CRC64;
MAFHSRSQRL SACLLICFSF MIRADGSRKL YIAYLGDKKH DDPSLVAASH HEMLSTILGS
KEEAIDSVAY SYKHGFSGFA AMLTEDQAEN LAELPEVISV TPNQKHELLT TRSWDFLGLN
YQRPSELLQR SNYGEDIIIG IIDTGIWPES RSFSDHGYGI IPPRWKGVCQ LGQEWGRTNC
SRKIIGARYY AAGLNKASHK LNYMSARDMN GHGTHTASTA AGSVVEGVSL HGLGEGVARG
GAPRARLAVY KVGWEEENGV YLTNAAVLAA MDDAIHDGVD ILSLSLAVDE DSFGALHAIQ
NGITVVYAGG NSGPRSQVLF NTAPWVITVA ASKIDRSFPT TITLGNKKKL IGQSLYYMLK
NESNSRFQTL VNGGNCSREA LNGTNIKGKV VLCIEITFGP VAKIFKDALA NVHSGGASGL
ILALYTTDFL VSTEGCQGMP CVLIDIDIGF QVLTYIGSQR LPIVKIEPAS SVTGKQVLAP
KVAMFSSRGP SIKYPTILKP DIAAPGVNIL AATKDAYVFN SGTSMATPHV AGVVALLKVL
HPQWSHAALK SAIITSASTK DEHGTPILAE ALPRKVADPF DYGGGNINPN GAADPGLIYD
IDPREYNKFF ECQIKKYEIC NITTKPAYHL NLPSISIPEL RHTIKVERTV TNVGKIDAVY
RSDIQSPLGV KIRVEPATLV FNSTKKVHTF KASIKPLWKV QGDYTFGSLT WYNEQHTVRI
PIAVRITIQD FYADVA
//
