ID K3XGG0_SETIT Unreviewed; 531 AA.
AC K3XGG0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL04490, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EnsemblPlants:KQL04490, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL04490,
RC ECO:0000313|Proteomes:UP000004995};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EnsemblPlants:KQL04490}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL04490};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Binds specifically and directly to substrates containing
CC either a simple or bipartite NLS motif. Promotes docking of import
CC substrates to the nuclear envelope. {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AGNK02002876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K3XGG0; -.
DR EnsemblPlants; KQL04490; KQL04490; SETIT_000891mg.
DR Gramene; KQL04490; KQL04490; SETIT_000891mg.
DR HOGENOM; CLU_516194_0_0_1; -.
DR Proteomes; UP000004995; Chromosome V.
DR ExpressionAtlas; K3XGG0; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF89; IMPORTIN SUBUNIT ALPHA-9; 1.
DR Pfam; PF00514; Arm; 2.
DR PIRSF; PIRSF005673; Importin_alpha; 2.
DR SMART; SM00185; ARM; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 57353 MW; 24B91B03E127F62C CRC64;
MAVSMTEGRR REEKLEDAAD ELRRRSSEMD DGSASASPSS ASPHQHHRDA IKSSVHNSAS
SRRREHAIAV GKERREALMR AKRVCRAPLS GNDETVMEEG DMVIDEKKAD LEAQTAQAVE
ELKSALSTQG KGAQKKKIEV LRALRRLLSQ SEVPPVEAAI KAGAIPLLVQ YLSFGSSDEQ
LLEAAWCLTN IAAGEPEETK SLLPALPLLI AHLGEKSSTL VAEQCAWAIG NVAGEGADLR
SKLLAQGALW PLARLMLSNK GSTARTAAWA LSNLIKGPDP KAANELISID GVLNAIIRNL
EKADEELATE VAWVVVYLSA LSEKATSLIV LRSLGNLVAG DGYMVDSVLT VGNSITDQAL
SSLIKCLKSD NRVLKKEASW AMSNIAAGSF EHKKLIFASE AMTLLMHLLT TAQFDIRREA
AYTLGNMCVV PAGNAAPPNI IVDHLVAIVN GGALPGFINL VRSADIESAR LGLQFLELVM
RGYPNGQGPK LVESEDGIEA MERFQFHENE LMRNMANGLV DKYFGEDYGL E
//
