ID K3XSQ4_SETIT Unreviewed; 875 AA.
AC K3XSQ4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
GN Name=101766822 {ECO:0000313|EnsemblPlants:KQL07469};
GN ORFNames=SETIT_5G359700v2 {ECO:0000313|EMBL:RCV27871.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV27871.1};
RN [1] {ECO:0000313|EMBL:RCV27871.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL07469,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV27871.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV27871.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV27871.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL07469}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL07469};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: May function as sodium-coupled metabolite transporter across
CC the chloroplast envelope. {ECO:0000256|ARBA:ARBA00003198}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast envelope
CC {ECO:0000256|ARBA:ARBA00004119}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000256|ARBA:ARBA00038341}.
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DR EMBL; AGNK02003342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003532; RCV27871.1; -; Genomic_DNA.
DR RefSeq; XP_004972230.1; XM_004972173.1.
DR AlphaFoldDB; K3XSQ4; -.
DR EnsemblPlants; KQL07469; KQL07469; SETIT_004955mg.
DR GeneID; 101766822; -.
DR Gramene; KQL07469; KQL07469; SETIT_004955mg.
DR KEGG; sita:101766822; -.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; K3XSQ4; -.
DR OMA; QVKVERW; -.
DR OrthoDB; 6504at2759; -.
DR Proteomes; UP000004995; Chromosome V.
DR GO; GO:0009941; C:chloroplast envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR PANTHER; PTHR32468:SF63; OS01G0817400 PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..447
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 690..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 94779 MW; 8D3197F566065ED0 CRC64;
MDAMPISDGL PTNVTAQIRN VTQPKASSNV VCYSPMMITT NGIWQGFNPL EFSLPLFILQ
TAIIVVTTRV LVLVLRPFRQ PRVIAEILAG VLLGPSVMGQ IETWATMVFP QRSLLTLETV
AHLGLLYFLF LVGLEMDIDV IRRSGKKALF VAIAGMALPF CMGIATSFIF RHQVSRNVHQ
TSFLLFLGVA LSVTAFPVLA RILAEIKLLG TELGRIAMSA AIVNDMCAWI LLALAIAISE
VNSAALSSLW VLLCGVLFVL FCFYAVRPGM WWLIRRTPEG EAVSDMQVSL ILTGVMLAGV
CTDAIGIHSV FGAFVYGLVI PTGPLGVVLI EKIEDFVTGL LLPLFFAISG LRTNVRKIGD
PITVGLLVLV FVMASFAKIM GTIIIAALYT MPFREGIALG FLMNTRGLVE MIVLNIGRDK
EVLDDESFAV MVLVSVAMTT LVTPVVTGVY RPSRRLVGYK RRNLQRIRHD SELRMLACVH
TTRNVPSVLS LLELSNPNKR SPIFIYALHL VELTGRASNM LAAAAASASK QSRSGTGSSL
PPVTEHIFNA FENYERHTGG VSIQTLAAVS PYQTMHEDVA VLAEDKHVSL IVVPFHKQQT
VDGGMEPINA HVRGFNESLL STSPCSVAIL VDRGLSAAAA RMATEHHVAL FFFGGPDDRE
ALAYAWRMVE HPGVTLTIVR FLPPDYRTPS VSGSSYRPSP ADADSRHITI STEGKSELEM
DEDYLNEFRT RNHGNEAISY STKMVANSEE TVAAIRSMDN NLHELYIVGR RPGQAGSPMT
AALEDWMENP ELGPIGDMLV SSDFSMAVSL LVVQQYVVAG APAPVPAPAA SSDPVRQYLS
NANQRPAAAA SAAYRTSAAS AANSRWSGSA GTVGF
//
