ID K3XUX2_SETIT Unreviewed; 1128 AA.
AC K3XUX2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SETIT_4G230600v2 {ECO:0000313|EMBL:RCV22561.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV22561.1};
RN [1] {ECO:0000313|EMBL:RCV22561.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL11599,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV22561.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV22561.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV22561.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL11599}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL11599};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000256|ARBA:ARBA00008684}.
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DR EMBL; AGNK02002632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003531; RCV22561.1; -; Genomic_DNA.
DR AlphaFoldDB; K3XUX2; -.
DR EnsemblPlants; KQL11599; KQL11599; SETIT_005729mg.
DR Gramene; KQL11599; KQL11599; SETIT_005729mg.
DR eggNOG; ENOG502QPYS; Eukaryota.
DR HOGENOM; CLU_000288_22_0_1; -.
DR InParanoid; K3XUX2; -.
DR OMA; CDEREND; -.
DR OrthoDB; 3681815at2759; -.
DR Proteomes; UP000004995; Chromosome IV.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27008; OS04G0122200 PROTEIN; 1.
DR PANTHER; PTHR27008:SF373; OS06G0586400 PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 11.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1128
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010126068"
FT TRANSMEM 768..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 823..1112
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 852
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1128 AA; 122370 MW; D4D1C1DA618F1D58 CRC64;
MAFWGIMPQF LVLLLCLVTL FGSLPEATCD ERENDQQALI CFKSQLSGPA DVFASWSNAS
LEFCSWHGVT CSKQPPRRVI ALDLASEGIT GTISPCIANL TSLTRLQLSN NSLHGSIPSE
LGLLSQLSSL NLSMNSLDGN IPSELSSCSQ LQILGLWNNS LHGEIPSVLS QCIHLQEINL
SNNNLEGSIP SPFGTLPELQ ILILANNKLS GAIPPSLGSS VSLKHVDLGR NAITGGIPES
LASSSSLRVL RLMRNSLSGE LPEALFNSSS LIAICLQENK FFGSIPPVTA TSPPVKHLHL
GGNSLSGIIP ASLGNLSSLL DLRLTRNKLA GSIPESIGYL PTLSLLNLNL NNLSGPVPPS
LFNMSSLTAL AMGNNSLSGR LPSHIGYTLP KIQILILTSN KFDGPVPASL VNAFNMKWLS
LGENRLTGPV PFFGSLPNLE ELDVSYNMLD AGDWGFLSSL SNCSRLTKLY LAGNNFQGEL
PSSIGNLSGS LEVLWLRDNK ISGPIPPEMG NLKNLNTLYM DYNRFTGSIP PTIGSMKNLV
VLAVAQNRLS GTIPDAIGNL VQLTDLKLDA NNLSGRIPES IGRCTQLQIL NLAHNALNGS
IPRSILKISS LSQEFDLSYN YLAGEIPEEI GNLINLNKLS ISNNMLSGRI PPSLGQCVLL
ECLKMQNNFF AGSIPQSFAE LVGIKELDIS RNNLSGKIPE FFTSLSYLHY LNLSFNNFDG
EVPRGGIFGN ASAVSIEGND QLCTSVLTAG IPLCSARSDD SKSKHKDLVL VAKIVIPIVI
ITLLCIATFF WRKRMQAQAH FQQFNKHMKN ITYDDIVKAT DMFSSTNLIG SGSFGRVYKG
SMKLHKDQVA IKIFNLSING AHRSFLAECE ALRNARHRNI VKIITLCSSV DPTGADFKAI
VFPNMLNGNL DMWLNQKAHS PRKILTLSQR INIALDLAYA MDYLHNQCAS PLIHCDLKPS
NILLDHDMVA YVSDFGLARF QCTKSSAHQD SSASLAGLKG SIGYIPPEYG MSQNISTTGD
VYSFGVLLLE MMTGCRPTDE KFSNGTSLHE FVDRAFPKNV EEVVDPTMLQ DDISATEVLQ
NCIIPLVKIG LSCSKTSPKE RPGMDKVSTE ILTIKNMFSS IHEHDQSK
//
