ID   K3XY44_SETIT            Unreviewed;       334 AA.
AC   K3XY44;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
GN   Name=101769209 {ECO:0000313|EnsemblPlants:KQL11664};
OS   Setaria italica (Foxtail millet) (Panicum italicum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX   NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL11664, ECO:0000313|Proteomes:UP000004995};
RN   [1] {ECO:0000313|EnsemblPlants:KQL11664, ECO:0000313|Proteomes:UP000004995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL11664,
RC   ECO:0000313|Proteomes:UP000004995};
RX   PubMed=22580951; DOI=10.1038/nbt.2196;
RA   Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA   Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA   Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA   Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA   Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA   Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT   "Reference genome sequence of the model plant Setaria.";
RL   Nat. Biotechnol. 30:555-561(2012).
RN   [2] {ECO:0000313|EnsemblPlants:KQL11664}
RP   IDENTIFICATION.
RC   STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL11664};
RG   EnsemblPlants;
RL   Submitted (AUG-2018) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; AGNK02002637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K3XY44; -.
DR   EnsemblPlants; KQL11664; KQL11664; SETIT_006784mg.
DR   Gramene; KQL11664; KQL11664; SETIT_006784mg.
DR   HOGENOM; CLU_007727_1_1_1; -.
DR   Proteomes; UP000004995; Chromosome IV.
DR   ExpressionAtlas; K3XY44; baseline.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR   CDD; cd09993; HDAC_classIV; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR   InterPro; IPR044150; HDAC_classIV.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF33; HISTONE DEACETYLASE 11; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT   DOMAIN          55..237
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   DOMAIN          247..319
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   334 AA;  36880 MW;  8A7613582ECC8C99 CRC64;
     MASSSASPAP APAGESLRQK RILSSKLYLE VPSSKAPVVY SPAYDISFLG LEKLHPFDSA
     KWGRICRYLT REGHLEKKQV VEPLEACKED LLVVHTEAYL NSLKCSFRVA SIVEVPPVSL
     VPNWIVQKKL LYPFRKQVGG SILSAKLALE RGWAINVGGG FHHCSAEEGG GFCAYADISL
     CIQFAFVRLN ISRLLIIDLD AHQGNGHEKD FANDGRVYIL DMYNAGIYPF DFTAKQYIDQ
     KVELAVCKSR FQPQLIVYNA GTDILDGDPL GRLKISPEGV ITRDEKVFRF AKDQNIPLLM
     LTSGGYMKSS ARVIADSIIN LANKNLIELG SQLG
//