ID K3YHY1_SETIT Unreviewed; 408 AA.
AC K3YHY1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=SAM-dependent MTase RsmB/NOP-type domain-containing protein {ECO:0000259|PROSITE:PS51686};
GN Name=101772479 {ECO:0000313|EnsemblPlants:KQL00927};
GN ORFNames=SETIT_6G074200v2 {ECO:0000313|EMBL:RCV30192.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV30192.1};
RN [1] {ECO:0000313|EMBL:RCV30192.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL00927,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV30192.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV30192.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV30192.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL00927}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL00927};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; AGNK02003586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003533; RCV30192.1; -; Genomic_DNA.
DR RefSeq; XP_012702591.1; XM_012847137.1.
DR RefSeq; XP_012702592.1; XM_012847138.1.
DR AlphaFoldDB; K3YHY1; -.
DR STRING; 4555.K3YHY1; -.
DR EnsemblPlants; KQL00927; KQL00927; SETIT_013851mg.
DR EnsemblPlants; KQL00928; KQL00928; SETIT_013851mg.
DR GeneID; 101772479; -.
DR Gramene; KQL00927; KQL00927; SETIT_013851mg.
DR Gramene; KQL00928; KQL00928; SETIT_013851mg.
DR KEGG; sita:101772479; -.
DR eggNOG; KOG2198; Eukaryota.
DR HOGENOM; CLU_039793_1_0_1; -.
DR InParanoid; K3YHY1; -.
DR OMA; AKLCMIA; -.
DR OrthoDB; 8499at2759; -.
DR Proteomes; UP000004995; Chromosome VI.
DR ExpressionAtlas; K3YHY1; baseline.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IBA:GO_Central.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR023269; RCMT_subfamily_9.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22807:SF16; S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 2.
DR PRINTS; PR02010; RCMT9.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 38..406
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 343
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 153
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 181
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 281
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 408 AA; 44599 MW; 90A527C2F60CDA92 CRC64;
MEETDCPEGS VPERIGEQQE ASLPLPPAFL EFLSENGLDP AVYSMAATIP RYIRLKPGME
SQVAEIEGEL KCGLEKVSWL PGFYAIPPEI QIAGSKAYQQ GKIYGIDAAS GAAILALDVR
PGDHVLDLCA APGAKLCMLA DMLGSTGSLT GVDVAKHRLS ACRTMLQKYS LGDRTRLFVA
DGTLFSILPV NSNLQRREGS IGLEENGSTF SEWTSRRSWK DRQKAKKANA TGSQHLLSSS
EPELIYYGKH SGLVGLRKSD VLCPAVDDEA CTSGYDKVLV DAECTHDGSI KHIQKFEFWG
WKTLDRRVLD AERTDNLFQL QLHLLTNGFR LLKIGGSLVY STCSMTVAQN ENVVQQFLST
QPSADLQKND LSDSWPCRSG GIPKTLRFDP ATSQTSGLFV AKFSKLPT
//
