ID K3YPN3_SETIT Unreviewed; 974 AA.
AC K3YPN3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN Name=101778281 {ECO:0000313|EnsemblPlants:KQL28281};
GN ORFNames=SETIT_1G049200v2 {ECO:0000313|EMBL:RCV05028.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL28281, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV05028.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL28281,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV05028.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV05028.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV05028.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL28281}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL28281};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; AGNK02000067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003528; RCV05028.1; -; Genomic_DNA.
DR RefSeq; XP_004951567.1; XM_004951510.3.
DR RefSeq; XP_004951568.1; XM_004951511.3.
DR AlphaFoldDB; K3YPN3; -.
DR STRING; 4555.K3YPN3; -.
DR EnsemblPlants; KQL28281; KQL28281; SETIT_016225mg.
DR GeneID; 101778281; -.
DR Gramene; KQL28281; KQL28281; SETIT_016225mg.
DR KEGG; sita:101778281; -.
DR eggNOG; KOG0207; Eukaryota.
DR HOGENOM; CLU_001771_0_3_1; -.
DR InParanoid; K3YPN3; -.
DR OMA; WECFFDE; -.
DR OrthoDB; 7279at2759; -.
DR Proteomes; UP000004995; Chromosome I.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR GO; GO:0043682; F:P-type divalent copper transporter activity; IBA:GO_Central.
DR GO; GO:0055070; P:copper ion homeostasis; IBA:GO_Central.
DR CDD; cd00371; HMA; 2.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR NCBIfam; TIGR00003; copper ion binding protein; 2.
DR PANTHER; PTHR46594:SF2; COPPER-TRANSPORTING ATPASE HMA4; 1.
DR PANTHER; PTHR46594; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 2.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 317..336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 381..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 581..602
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 903..926
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 932..952
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 34..100
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 108..174
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 183..249
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 104882 MW; 764749BBFA664CCB CRC64;
MEQNGGSHLK EPLLPASSGA SPAGASPRKE RKTGKIMFSV RGISCASCAV SIETVVAGLK
GVESIQVSPL QGQAVVQYRP EETDARTIKE AIEELNFEVD ELHEQEIAVC RLRIKGMACT
SCSESVERAL QMVPGVKKAA VGLALEEAKV HYDPNVTSRD LIIEAVEDAG FGADLISSGD
DVNKVHLKLE GLSSPEDTKL IQTALETAEG ANHVEWDTVQ QTIKVAYDPD ITGPRLLIQC
IQNAAQPPKC FNATLHSPPK QREAERNHEI RNYRNQFLWS CLFSVPVFLF SMVLPMISPY
GDWLSYRICN NMTIGMLLRW LLCSPVQFIV GWRFYIGAYH ALKRGYSNMD VLVALGTNAA
YFYSVYIVLK ALTSASFEGQ DFFETSAMLV SFILLGKYLE VVAKGKTSDA LSKLTELAPE
TACLLSFDKD GNVISETEIS TQLLQRNDVI KIVPGTKVPV DGVVIKGQSH VNESMITGEA
RPIAKKPGDR VIGGTVNDNG CIIVKATHVG SETALSQIVQ LVEAAQLARA PVQKLADKIS
RFFVPTVVVV AFLTWLGWFI PGQFHLYPAQ WIPKGMDSFE LALQFGISVL VVACPCALGL
ATPTAVMVAT GKGASQGVLI KGGNALEKAH KIKAIIFDKT GTLTVGKPSV VQTKIFSKIP
LLELCDLAAG AEANSEHPLS KAIVEHTKKL REQYGSHSDH MMESRDFEVH PGAGVSANVE
GKLVLVGNKR LMQEFEIPLS PEVEAYMSET EELARTCVLV AIDKIICGAL AVSDPLKPEA
GHVISYLNSM GISSIMVTGD NWATAKSIAK EVGISQVFAE IDPVGKAEKI KDLQMQGLTV
AMVGDGINDS PALAAADVGM AIGAGTDVAI EAADIVLMKS SLEDVITAID LSRKTLSRIR
LNYVWALGYN VLGMPVAAGV LFPFTGIRLP PWLAGACMAA SSVSVVCSSL LLQLYKKPLH
VEDAPRPTDG SDLV
//
