ID K3YQC4_SETIT Unreviewed; 718 AA.
AC K3YQC4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Phenylalanine ammonia-lyase {ECO:0000256|RuleBase:RU003955};
DE EC=4.3.1.24 {ECO:0000256|RuleBase:RU003955};
GN Name=101780720 {ECO:0000313|EnsemblPlants:KQL30568};
GN ORFNames=SETIT_1G240300v2 {ECO:0000313|EMBL:RCV07387.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL30568, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV07387.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL30568,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV07387.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV07387.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV07387.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL30568}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL30568};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine = (E)-cinnamate + NH4(+);
CC Xref=Rhea:RHEA:21384, ChEBI:CHEBI:15669, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58095; EC=4.3.1.24;
CC Evidence={ECO:0000256|RuleBase:RU003955};
CC -!- PATHWAY: Phenylpropanoid metabolism; trans-cinnamate biosynthesis;
CC trans-cinnamate from L-phenylalanine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005138, ECO:0000256|RuleBase:RU003955}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU003955}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|ARBA:ARBA00007238, ECO:0000256|RuleBase:RU003954}.
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DR EMBL; AGNK02000444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003528; RCV07387.1; -; Genomic_DNA.
DR RefSeq; XP_004953154.1; XM_004953097.3.
DR AlphaFoldDB; K3YQC4; -.
DR SMR; K3YQC4; -.
DR STRING; 4555.K3YQC4; -.
DR EnsemblPlants; KQL30568; KQL30568; SETIT_016467mg.
DR GeneID; 101780720; -.
DR Gramene; KQL30568; KQL30568; SETIT_016467mg.
DR KEGG; sita:101780720; -.
DR eggNOG; KOG0222; Eukaryota.
DR HOGENOM; CLU_014801_3_0_1; -.
DR InParanoid; K3YQC4; -.
DR OMA; YSLRCMP; -.
DR OrthoDB; 390692at2759; -.
DR UniPathway; UPA00713; UER00725.
DR Proteomes; UP000004995; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016841; F:ammonia-lyase activity; IBA:GO_Central.
DR GO; GO:0045548; F:phenylalanine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0009800; P:cinnamic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:InterPro.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR InterPro; IPR005922; Phe_NH3-lyase.
DR InterPro; IPR023144; Phe_NH3-lyase_shielding_dom_sf.
DR NCBIfam; TIGR01226; phe_am_lyase; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF80; PHENYLALANINE AMMONIA-LYASE 2; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU003954};
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051,
KW ECO:0000256|RuleBase:RU003955};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995}.
SQ SEQUENCE 718 AA; 77804 MW; E6780602457EFC8B CRC64;
MECETGLVRS LHGDGLCMSA QAAAPRADPL NWGKAAEDLS GSHLDEVKRM VAEFREPLVK
IQGASLSIAQ VAAVAAGAGE ARVELDESAR ERVKASSDWV MNSMMNGTDS YGVTTGFGAT
SHRRTKEGGA LQRELIRFLN AGAFGTGADG HVLPAEATRA AMLVRINTLL QGYSGIRFEI
LETIAKLLNA NVTPCLPLRG TITASGDLVP LSYIAGLITG RQNSVAVAPD GRKVDAAEAF
KIAGIEHGFF ELQPKEGLAM VNGTAVGSGL ASTVLFEANV LAIMAEVISA VFCEVMTGKP
EFTDHLTHKL KHHPGQIEAA AIMEHILEGS SYMKLAKKLG ELDPLMKPKQ DRYALRTSPQ
WLGPQIEVIR FATKSIEREI NSVNDNPLID VSRGKALHGG NFQGTPIGVS MDNTRLALAA
IGKLMFAQFS ELVNDFYNNG LPSNLSGGRN PSLDYGFKGA EIAMASYCSE LQFLGNPVTN
HVQSAEQHNQ DVNSLGLISS RKTAEAIEIL KLMTSTFLIA LCQAIDLRHL EENMKAAVKN
CVTQVAKKTL SMNAMGGLHI ARFCEKDLQT AIDREAVFAY ADDPCSPNYP LMQKLRAVLI
EHALANGDAE RVVETSIFAK VAEFEQQVRA ALPKEVEAAR AAVESGRPMV PNRIKECRSY
PLYRFVREEL GAEYLTGEKT RSPGEELNKV LVAINERKHI DPLLECLKEW NGEPLPLC
//
