ID K3YQM1_SETIT Unreviewed; 673 AA.
AC K3YQM1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL31420, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EnsemblPlants:KQL31420, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL31420,
RC ECO:0000313|Proteomes:UP000004995};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EnsemblPlants:KQL31420}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL31420};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; AGNK02000541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K3YQM1; -.
DR STRING; 4555.K3YQM1; -.
DR EnsemblPlants; KQL31420; KQL31420; SETIT_016564mg.
DR Gramene; KQL31420; KQL31420; SETIT_016564mg.
DR eggNOG; KOG2657; Eukaryota.
DR HOGENOM; CLU_029323_0_0_1; -.
DR InParanoid; K3YQM1; -.
DR OMA; ECVYPGV; -.
DR Proteomes; UP000004995; Chromosome I.
DR GO; GO:0005798; C:Golgi-associated vesicle; IEA:EnsemblPlants.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..673
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010127016"
FT DOMAIN 50..207
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 673 AA; 72424 MW; BAF0E984F925D79B CRC64;
MAAGSALSLV AAAVCLALAV LAPAVSGDGA TLESVPDLVK AMYRNIESFP CVRLLNLSGE
IGCSNPGSEK IIAPIVRFKK GSDHLVQPST VLLPLDQMSD FFLRVSNNPE FHQKVSGVLI
ESNGANNNLQ ELSPDRKFPQ DAFAPYSNRS HDWNPAGSGI MWNRYDFPVF LLSEESTQTL
REVSEKNEKT DNGYKANVAE FDLIMQTTKA QTHDSASCLK EHSCLPLGGH SVWASLPPIK
NGSAEHQKPI ILAITSQDSA SFFRDRSIGS DSPISGLIAL LTAVDALSHI PDLSNLKKQL
VFAVFNGEAW GYLGSRRFLH ELDEGAHSVN GINSLMIDQV LEIGSVGQAV IEEYPSFYAH
AAGNSSASKK ILDALQSASK SLGSDNVKVK QAASSNPGVP PSSLMSFIRK NMSTSGVVLE
DFDSHFSNRF YHSHLDNPAN INSSSIAAAA ALAARSLYIL ASADSVVDLM TLNTIKVNVS
LVKELVGCLL SCNPGFSCDL VKSFISPSSS SCPSHYVGVF LDDPSGTQFP SYADDTSRFV
WNFLADRTST SVGNKSSCTG KCGDEGEVCI RAEVEGGGRC VVSTTRYVPA YSTRVKFEDN
AWHVLPANSS DPMGVVDPVW TESYWNTIGL RVYAVQDSTY DWLILLAGLS VTTASYCAVH
VGRAYISKVV KRD
//
